Evidence-based treatment of pain in chemotherapy-induced peripheral neuropathy

RS D'Souza, GAM Alvarez… - Current Pain and …, 2023 - Springer
Abstract Purpose of Review Chemotherapy-induced peripheral neuropathy (CIPN) is a
debilitating and often painful condition that occurs after administration of chemotherapeutic …

Mechanism-based pharmacological management of chemotherapy-induced neuropathic pain from preclinical studies to clinical prospective: platinum-based drugs …

N Zafari, M Velayati, M Maftooh… - Current …, 2023 - ingentaconnect.com
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a painful condition,
experienced by patients undergoing chemotherapy with some specific drugs, such as …

Single-cell analysis of dorsal root ganglia reveals metalloproteinase signaling in satellite glial cells and pain

R Tonello, AS Prudente, SH Lee, CF Cohen… - Brain, Behavior, and …, 2023 - Elsevier
Satellite glial cells (SGCs) are among the most abundant non-neuronal cells in dorsal root
ganglia (DRGs) and closely envelop sensory neurons that detect painful stimuli. However …

Targeting translation: A review of preclinical animal models in the development of treatments for chemotherapy‐induced peripheral neuropathy

D White, M Abdulla, SB Park… - Journal of the …, 2023 - Wiley Online Library
Abstract Background and Aims The expanding use of chemotherapy in curative cancer
treatment has simultaneously resulted in a substantial and growing cohort of cancer …

Calcium signaling in chemotherapy-induced neuropathy

M de Castro Fonseca, PHS Marazzi-Diniz, MF Leite… - Cell Calcium, 2023 - Elsevier
Abstract Alterations in calcium (Ca 2+) signaling is a major mechanism in the development
of chemotherapy-induced peripheral neuropathy (CIPN), a side effect caused by multiple …

Preclinical research in paclitaxel-induced neuropathic pain: a systematic review

C Bacalhau, JT Costa-Pereira… - Frontiers in Veterinary …, 2023 - frontiersin.org
Introduction Chemotherapy-induced peripheral neuropathy (CIPN) is a common
consequence of cancer treatment and pain is a frequent complaint of the patients. Paclitaxel …

[PDF][PDF] Prevention and therapy of chemotherapy-induced peripheral neuropathy: a review of recent findings

Z Michalova, E Szekiova, J Blasko, I Vanicky - Neoplasma, 2023 - researchgate.net
Chemotherapy-induced peripheral neuropathy is one of the most frequent dose-limiting side
effects, observed in patients receiving antineoplastic agents, persisting for up to two years …

PGC1α: An emerging therapeutic target for chemotherapy-induced peripheral neuropathy

M Zhai, H Hu, Y Zheng, B Wu… - Therapeutic Advances in …, 2023 - journals.sagepub.com
Chemotherapy-induced peripheral neuropathy (CIPN)-mediated paresthesias are a
common complication in cancer patients undergoing chemotherapy. There are currently no …

Trimetazidine alleviates paclitaxel-induced peripheral neuropathy through modulation of TLR4/p38/NF-κB and klotho protein expression

ASA Hammad, MM Sayed-Ahmed, SMNA Hafez… - Chemico-Biological …, 2023 - Elsevier
Chemotherapy-induced peripheral neuropathy is a common adverse effect associated with
a number of chemotherapeutic agents including paclitaxel (PTX) which is used in a wide …

The Antinociceptive Effect of Sympathetic Block is Mediated by Transforming Growth Factor β in a Mouse Model of Radiculopathy

DD Lückemeyer, W Xie, AS Prudente, KA Qualls… - Neuroscience …, 2023 - Springer
Although sympathetic blockade is clinically used to treat pain, the underlying mechanisms
remain unclear. We developed a localized microsympathectomy (mSYMPX), by cutting the …