Telomerase is a ribonucleoprotein (RNP) responsible for the maintenance of chromosomal
integrity by stabilizing telomere length. Telomerase is a widely expressed hallmark …

The telomerase reverse transcriptase (TERT) promoter mutations are associated with
increased TERT mRNA and TERT protein levels, telomerase activity, and shorter but stable …

Cancer stem cells (CSCs) play an important role in cancer development. Based on
advancements in CSC research, we propose a monophyletic model of cancer. This model is …

Cellular senescence has long been considered a permanent state of cell cycle arrest
occurring in proliferating cells subject to different stressors, used as a cellular defense …

Background It has been demonstrated that elevated telomerase reverse transcriptase
(TERT) expression or activity is implicated in pulmonary hypertension (PH). In addition …

Telomerase can overcome replicative senescence by elongation of telomeres but is also a
specific element in most cancer cells. It is expressed more vastly than any other tumor …

As a major cancer hallmark, there is a sustained interest in understanding the telomerase
contribution to carcinogenesis in order to therapeutically target this enzyme. This is …

Objective: The telomerase gene is overexpressed in the majority of tumors and cancers
compared to normal and healthy cells, and on the other hand, this enzymatic protein is …

Telomerase determines cell lifespan by controlling chromosome stability and cell viability,
m6A epigenetic modification plays an important role in the regulation of telomerase activity …

The syntheses of novel 2, 4-bis [(substituted-aminomethyl) phenyl] phenylquinazolines 12
and 2, 4-bis [(substituted-aminomethyl) phenyl] phenylquinolines 13 are reported here in six …