[HTML][HTML] Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential
M Yuan, B Yang, G Rothschild, JJ Mann… - Signal transduction and …, 2023 - nature.com
Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …
[HTML][HTML] Predicting treatment outcome in depression: an introduction into current concepts and challenges
Improving response and remission rates in major depressive disorder (MDD) remains an
important challenge. Matching patients to the treatment they will most likely respond to …
important challenge. Matching patients to the treatment they will most likely respond to …
[HTML][HTML] The unique face of comorbid anxiety and depression: increased interoceptive fearfulness and reactivity
Anxiety and depression commonly co-occur, yet the underlying brain and behavioral
processes are poorly understood. Here we examined the hypothesis that individuals with …
processes are poorly understood. Here we examined the hypothesis that individuals with …
Association between decreased interhemispheric functional connectivity of the insula and duration of illness in recurrent depression
ZP Guo, L Chen, LR Tang, Y Gao, T Chand… - Journal of Affective …, 2023 - Elsevier
Objective To investigate the altered interhemispheric functional connectivity in the resting
state in patients with recurrent major depressive disorder (MDD). Methods Voxel-mirrored …
state in patients with recurrent major depressive disorder (MDD). Methods Voxel-mirrored …
[HTML][HTML] Vortioxetine in patients with major depressive disorder and high levels of anxiety symptoms: an updated analysis of efficacy and tolerability
M Adair, MC Christensen, I Florea, H Loft… - Journal of Affective …, 2023 - Elsevier
Background Patients with major depressive disorder (MDD) often experience comorbid
anxiety symptoms. Vortioxetine has demonstrated efficacy in treating anxiety symptoms in …
anxiety symptoms. Vortioxetine has demonstrated efficacy in treating anxiety symptoms in …
The role of sleep effort as a mediator between anxiety and depression
C Borges, JG Ellis… - Psychological Reports, 2023 - journals.sagepub.com
Depression, anxiety, and insomnia are all conditions that share a complex bidirectional
relationship. Sleep effort is a construct with cognitive and behavioral components that …
relationship. Sleep effort is a construct with cognitive and behavioral components that …
[HTML][HTML] Multimodal data integration advances longitudinal prediction of the naturalistic course of depression and reveals a multimodal signature of remission during 2 …
Background The ability to predict the disease course of individuals with major depressive
disorder (MDD) is essential for optimal treatment planning. Here, we used a data-driven …
disorder (MDD) is essential for optimal treatment planning. Here, we used a data-driven …
The prevalence and clinical correlates of anxiety in Chinese patients with first-episode and drug-naive major depressive disorder at different ages of onset
X Wang, Q Wang, H Ren, X Wang, J Tang… - Journal of affective …, 2023 - Elsevier
Background Major depressive disorder (MDD) with comorbid anxiety is very common and is
associated with worse clinical outcomes. MDD patients at different ages of onset may have …
associated with worse clinical outcomes. MDD patients at different ages of onset may have …
Positive relations mediate the bidirectional connections between depression and anxiety symptoms
Introduction Major depressive disorder (MDD) and generalized anxiety disorder (GAD) co-
occur at high rates, often preceding and predicting one another over long durations …
occur at high rates, often preceding and predicting one another over long durations …
Effectiveness of vortioxetine in patients with major depressive disorder and co-morbid generalized anxiety disorder in routine clinical practice: A subgroup analysis of …
SS Almeida, MC Christensen… - Journal of …, 2023 - journals.sagepub.com
Background: Generalized anxiety disorder (GAD) is commonly co-morbid with major
depressive disorder (MDD) and is associated with greater functional impairment and poorer …
depressive disorder (MDD) and is associated with greater functional impairment and poorer …