[HTML][HTML] Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

NLRP3 inflammasome and interleukin-1 contributions to COVID-19-associated coagulopathy and immunothrombosis

N Potere, E Garrad, Y Kanthi, M Di Nisio… - Cardiovascular …, 2023 - academic.oup.com
Immunothrombosis—immune-mediated activation of coagulation—is protective against
pathogens, but excessive immunothrombosis can result in pathological thrombosis and …

Randomized trial of anticoagulation strategies for noncritically ill patients hospitalized with COVID-19

GW Stone, ME Farkouh, A Lala, E Tinuoye… - Journal of the American …, 2023 - jacc.org
Background Prior studies of therapeutic-dose anticoagulation in patients with COVID-19
have reported conflicting results. Objectives We sought to determine the safety and …

Novel tissue factor inhibition for thromboprophylaxis in COVID-19: primary results of the ASPEN-COVID-19 trial

CN Hess, J Hsia, IA Carroll, MR Nehler… - … and Vascular Biology, 2023 - Am Heart Assoc
BACKGROUND: Thrombo-inflammation is central to COVID-19-associated coagulopathy. TF
(tissue factor), a driver of disordered coagulation and inflammation in viral infections, may be …

In situ pulmonary arterial thrombosis: Literature review and clinical significance of a distinct entity

L Baranga, S Khanuja, JA Scott… - American Journal of …, 2023 - Am Roentgen Ray Soc
Please see the Editorial Comment by Andetta Hunsaker discussing this article. Filling
defects identified in the pulmonary arterial tree are commonly presumed to represent an …

Sequelae of long COVID, known and unknown: A review of updated information

T Asakawa, Q Cai, J Shen, Y Zhang, Y Li, P Chen… - Bioscience …, 2023 - jstage.jst.go.jp
Over three years have passed since the COVID-19 pandemic started. The dangerousness
and impact of COVID-19 should definitely not be ignored or underestimated. Other than the …

COVID-19 Patients with pulmonary hypertension hospitalized in the United States during the early pandemic: analysis of in-hospital mortality, clinical outcomes, and …

H Majeed, B Cannon, K Raj, A Nasrullah… - Current Problems in …, 2023 - Elsevier
Abstract Coronavirus Disease 2019 (COVID-19) has been linked to severe consequences
among hospitalized patients diagnosed with pulmonary hypertension (PH), as evidenced by …

Ischemic stroke and intracranial hemorrhage in extracorporeal membrane oxygenation for COVID-19: A systematic review and meta-analysis

Y Jin, Y Zhang, J Liu - Perfusion, 2023 - journals.sagepub.com
Purpose Extracorporeal membrane oxygenation (ECMO) is employed to support critically ill
COVD-19 patients. The occurrence of ischemic stroke and intracranial hemorrhage (ICH), as …

Enoxaparin improves COVID-19 by reducing Neutrophils Extracellular Traps (NETs) production

ES Córneo, FP Veras, GF Gomes, AH Schneider… - Clinical …, 2023 - Elsevier
Background COVID-19 causes consequences such as imbalance of the immune system and
thrombotic events. During the infection process, NETs in excess induce a pro-inflammatory …

COVID-19 thromboprophylaxis. New evidence

R Ferrandis, P Sierra, A Gomez-Luque - Revista Española de …, 2023 - Elsevier
Recent publications have questioned the efficacy of using therapeutic or intermediate doses
of low molecular weight heparin in COVID-19 patients, especially in the most severe …