Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international Consensus Statement

S Petersenn, M Fleseriu, FF Casanueva… - Nature Reviews …, 2023 - nature.com
Abstract This Consensus Statement from an international, multidisciplinary workshop
sponsored by the Pituitary Society offers evidence-based graded consensus …

Biological and therapeutic implications of the tumor microenvironment in pituitary adenomas

MD Ilie, A Vasiljevic, P Bertolino, G Raverot - Endocrine reviews, 2023 - academic.oup.com
Pituitary adenomas (PAs) are neoplasms derived from the endocrine cells of the anterior
pituitary gland. Most frequently, they are benign tumors, but may sometimes display an …

Aggressive pituitary tumors and pituitary carcinomas: from pathology to treatment

P Burman, O Casar-Borota… - The Journal of …, 2023 - academic.oup.com
Aggressive pituitary tumors (APTs) and pituitary carcinomas (PCs) are heterogeneous with
regard to clinical presentation, proliferative markers, clinical course, and response to …

Pituitary adenoma or neuroendocrine tumour: the need for an integrated prognostic classification

KKY Ho, UB Kaiser, P Chanson, M Gadelha… - Nature Reviews …, 2023 - nature.com
In the 2022 fifth edition of the WHO Classification of Endocrine Tumours and of Central
Nervous System Tumours, pituitary adenomas are reclassified as neuroendocrine tumours …

Therapeutic targeting of the pituitary tumor microenvironment

MD Ilie, D De Alcubierre, AL Carretti… - Pharmacology & …, 2023 - Elsevier
The tumor microenvironment (TME), the complex environment in which tumors develop, has
been increasingly targeted for cancer treatment in recent years. Aggressive pituitary tumors …

Prevalence and clinical correlations of SF3B1 variants in lactotroph tumours

J Simon, LG Perez-Rivas, Y Zhao… - European journal of …, 2023 - academic.oup.com
Objective A somatic mutational hotspot in the SF3B1 gene was reported in lactotroph
tumours. The aim of our study was to examine the prevalence of driver SF3B1 variants in a …

An individualized approach to the management of Cushing disease

M Fleseriu, EV Varlamov, JM Hinojosa-Amaya… - Nature Reviews …, 2023 - nature.com
Cushing disease caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary
corticotroph adenoma leads to hypercortisolaemia with high mortality due to metabolic …

The immune microenviroment in somatotropinomas: from biology to personalized and target therapy

S Chiloiro, L De Marinis - Reviews in Endocrine and Metabolic Disorders, 2023 - Springer
Pituitary tumors are rare neoplasms, with a heterogeneous biological and clinical behavior,
due to their clinical course, local invasive growth, resistance to conventional therapies and …

Position statement on the diagnosis and management of acromegaly: the French National Diagnosis and Treatment Protocol (NDTP)

T Brue, H Rahabi, A Barry, A Barlier, J Bertherat… - Annales d' …, 2023 - Elsevier
Acromegaly is a rare disease with prevalence of approximately 60 cases per million, slight
female predominance and peak onset in adults in the fourth decade. Clinical diagnosis is …

Radiotherapy in aggressive or dopamine agonists resistant prolactinomas; is it still worthwhile?

DA Niculescu, ML Gheorghiu… - European Journal of …, 2023 - academic.oup.com
Radiotherapy, conventional or radiosurgery, has been used to control prolactin secretion
and tumour growth in prolactinomas both as part of multimodal therapy or rarely as primary …