Copper metabolism in cell death and autophagy
Copper is an essential trace element in biological systems, maintaining the activity of
enzymes and the function of transcription factors. However, at high concentrations, copper …
enzymes and the function of transcription factors. However, at high concentrations, copper …
GPX4 in cell death, autophagy, and disease
ABSTRACT Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …
Copper-dependent autophagic degradation of GPX4 drives ferroptosis
Ferroptosis is a type of iron-dependent regulated cell death characterized by unrestricted
lipid peroxidation and membrane damage. Although GPX4 (glutathione peroxidase 4) plays …
lipid peroxidation and membrane damage. Although GPX4 (glutathione peroxidase 4) plays …
Hallmarks of cardiovascular ageing
Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …
[HTML][HTML] SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
U Gioia, S Tavella, P Martínez-Orellana, G Cicio… - Nature Cell …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …
[HTML][HTML] A bioinformatics analysis, pre-clinical and clinical conception of autophagy in pancreatic cancer: complexity and simplicity in crosstalk
Pancreatic cancer (PC) is a serious gastrointestinal tract disease for which the 5-year
survival rate is less than 10%, even in developed countries such as the USA. The genomic …
survival rate is less than 10%, even in developed countries such as the USA. The genomic …
Autophagy-dependent ferroptosis in cancer
Significance: Autophagy is a self-degrading process that determines cell fate in response to
various environmental stresses. In contrast to autophagy-mediated cell survival, the signals …
various environmental stresses. In contrast to autophagy-mediated cell survival, the signals …
TMEM164 is a new determinant of autophagy-dependent ferroptosis
J Liu, Y Liu, Y Wang, C Li, Y Xie, DJ Klionsky, R Kang… - Autophagy, 2023 - Taylor & Francis
ABSTRACT Macroautophagy (hereafter “autophagy”) is a membrane-mediated biological
process that involves engulfing and delivering cytoplasmic components to lysosomes for …
process that involves engulfing and delivering cytoplasmic components to lysosomes for …
Tubular cells produce FGF2 via autophagy after acute kidney injury leading to fibroblast activation and renal fibrosis
MJ Livingston, S Shu, Y Fan, Z Li, Q Jiao, XM Yin… - Autophagy, 2023 - Taylor & Francis
Following acute kidney injury (AKI), renal tubular cells may stimulate fibroblasts in a
paracrine fashion leading to interstitial fibrosis, but the paracrine factors and their regulation …
paracrine fashion leading to interstitial fibrosis, but the paracrine factors and their regulation …
[HTML][HTML] Mitochondrial hypermetabolism precedes impaired autophagy and synaptic disorganization in App knock-in Alzheimer mouse models
Accumulation of amyloid β-peptide (Aβ) is a driver of Alzheimer's disease (AD). Amyloid
precursor protein (App) knock-in mouse models recapitulate AD-associated Aβ pathology …
precursor protein (App) knock-in mouse models recapitulate AD-associated Aβ pathology …