Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective
Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
Synthesis of novel scaffolds based on bis-thiazole or bis-triazolothiadiazine linked to quinoxaline as new hybrid molecules
A synthesis of novel bis-thiazoles, linked to quinoxaline as novel hybrid molecules, was
accomplished in good yields by the reaction of the appropriate α-haloketones or α-keto …
accomplished in good yields by the reaction of the appropriate α-haloketones or α-keto …
Design, synthesis, and biological evaluation of phenylurea indole derivatives as ABCG2 inhibitors
Three series of phenylurea indole derivatives were synthesized with potent inhibitory
activities on ABCG2 with simple and efficient synthetic routes. Among these compounds …
activities on ABCG2 with simple and efficient synthetic routes. Among these compounds …
Synthesis of novel bis-thiazoles, bis-thienopyridines, and bis-triazolothiadiazines linked to diphenyl ether core as novel hybrid molecules
AHM Elwahy, ARS Ginidi, MR Shaaban… - Synthetic …, 2023 - Taylor & Francis
The reaction of the appropriate α-haloketones or α-keto-hydrazonoyl chlorides with the
corresponding bis (hydrazinecarbothioamide) in EtOH at reflux in the presence of a few …
corresponding bis (hydrazinecarbothioamide) in EtOH at reflux in the presence of a few …
Synthesis, X-ray crystal structure, Hirshfeld surface analysis and computational investigation into the potential inhibitory action of novel 6-(p-tolyl)-2-((p-tolyl)thio)methyl-7H-[1.2 …
In recent times, the novel coronavirus disease (COVID-19) caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has now become a worldwide pandemic …
respiratory syndrome coronavirus 2 (SARS-CoV-2) has now become a worldwide pandemic …
INHIBITORS OF BROMODOMAIN-4 AND CYCLOOXYGENASE-2: A REVIEW ON THE ADVANTAGEOUS EFFECT OF DUAL-TARGET APPROACH IN CANCER …
E SINGH - International Journal of Chemistry Research, 2023 - ijcr.info
The main objective of this review article is to establish a correlation between the roles of
BRD-4 and COX-2 inhibitors in anticancer treatment. This article aims to project the …
BRD-4 and COX-2 inhibitors in anticancer treatment. This article aims to project the …