Arthritis is a common degenerative disease of joints, which has become a public health
problem affecting human health, but its pathogenesis is complex and cannot be eradicated …

Objective Psoriatic arthritis (PsA) is an immune‐mediated inflammatory arthritis, associated
with psoriasis, that significantly increases morbidity and mortality risk. We currently lack the …

Objective The current study evaluated various new colchicine analogs for their anticancer
activity and to study the primary mechanism of apoptosis and in vivo antitumor activity of the …

The aim of this study was to evaluate the anti-allergic potentials of dactolisib, a dual
PI3K/mTOR kinase inhibitor, on two important events for allergy: sensitization and the onset …

As a member of the class I PI3K family, phosphoinositide 3-kinase δ (PI3K δ) is an important
signaling biomolecule that controls immune cell differentiation, proliferation, migration, and …

Cuproptosis is a newfound cell death form that depends on copper (Cu) ionophores to
transport Cu into cancer cells. Studies on the relationship have covered most common …

Herein we present the development of highly productive and chemoselective ester reduction
in a continuous flow system with lithium aluminum hydride (LAH) at mild temperature. The …

Abstract PD105, a PI3Kδ inhibitor, is a candidate for the treatment of rheumatoid arthritis.
This study aims to identify the metabolic profiling in vitro and in vivo by UHPLC-Q-Exactive …

Herein we present the development of highly productive and chemoselective ester reduction
in a continuous flow system with lithium aluminum hydride (LAH) at mild temperature. The …