[HTML][HTML] PI3K/AKT signaling pathway as a critical regulator of epithelial-mesenchymal transition in colorectal tumor cells
A Maharati, M Moghbeli - Cell Communication and Signaling, 2023 - Springer
Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignancies that are
considered as a global health challenge. Despite many progresses in therapeutic methods …
considered as a global health challenge. Despite many progresses in therapeutic methods …
[HTML][HTML] Cognitive impairment in multiple sclerosis
K Maiese - Bioengineering, 2023 - mdpi.com
Almost three million individuals suffer from multiple sclerosis (MS) throughout the world, a
demyelinating disease in the nervous system with increased prevalence over the last five …
demyelinating disease in the nervous system with increased prevalence over the last five …
Targeting the alternative vitamin E metabolite binding site enables noncanonical PPARγ modulation
S Arifi, JA Marschner, J Pollinger, L Isigkeit… - Journal of the …, 2023 - ACS Publications
The lipid-sensing transcription factor PPARγ is the target of antidiabetic thiazolidinediones
(TZD). At two sites within its ligand binding domain, it also binds oxidized vitamin E …
(TZD). At two sites within its ligand binding domain, it also binds oxidized vitamin E …
[HTML][HTML] Systems and in vitro pharmacology profiling of diosgenin against breast cancer
Aim: The purpose of this study was to establish a mode of action for diosgenin against breast
cancer employing a range of system biology tools and to corroborate its results with …
cancer employing a range of system biology tools and to corroborate its results with …
[HTML][HTML] Clinical significance of oxidative stress markers as angioinvasion and metastasis indicators in papillary thyroid cancer
A Buczyńska, I Sidorkiewicz, M Kościuszko… - Scientific Reports, 2023 - nature.com
Angioinvasion remains the important prognostic feature in papillary thyroid cancer (PTC)
patients. Literature data indicates several markers that may be associated with oxidative …
patients. Literature data indicates several markers that may be associated with oxidative …
A network pharmacology approach and experimental validation to investigate the anticancer mechanism and potential active targets of ethanol extract of Wei-Tong …
F Lin, G Zhang, X Yang, M Wang, R Wang… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Wei-Tong-Xin (WTX), derives from the Chinese
herbal decoction (CHD) of Wan-Ying-Yuan in ancient China, has been shown to be effective …
herbal decoction (CHD) of Wan-Ying-Yuan in ancient China, has been shown to be effective …
METTL3-mediated m6A mRNA modification was involved in cadmium-induced liver injury
W Li, M Tan, H Wang, Z Wang, Y Pang, R Yang… - Environmental …, 2023 - Elsevier
Cadmium is an environmental pollutant that has extensive deleterious effects. However, the
mechanisms underlying the hepatotoxicity induced by long-term exposure to cadmium …
mechanisms underlying the hepatotoxicity induced by long-term exposure to cadmium …
[HTML][HTML] Innovative therapeutic strategies for cardiovascular disease
K Maiese - EXCLI journal, 2023 - ncbi.nlm.nih.gov
As a significant non-communicable disease, cardiovascular disease is the leading cause of
death for both men and women, comprises almost twenty percent of deaths in most racial …
death for both men and women, comprises almost twenty percent of deaths in most racial …
[HTML][HTML] Molecular and metabolic mechanisms of bufalin against lung adenocarcinoma: New and comprehensive evidences from network pharmacology …
S Shi, S Zhao, X Tian, F Liu, X Lu, H Zang, F Li… - Computers in Biology …, 2023 - Elsevier
Background This study aims to evaluate the efficacy and therapeutic mechanism of bufalin
on lung adenocarcinoma (LUAD) through a comprehensive strategy integrating network …
on lung adenocarcinoma (LUAD) through a comprehensive strategy integrating network …
[HTML][HTML] Application of luteolin in neoplasms and nonneoplastic diseases
K Rakoczy, J Kaczor, A Sołtyk, N Szymańska… - International Journal of …, 2023 - mdpi.com
Researchers are amazed at the multitude of biological effects of 3′, 4′, 5, 7-
tetrahydroxyflavone, more commonly known as luteolin, as it simultaneously has antioxidant …
tetrahydroxyflavone, more commonly known as luteolin, as it simultaneously has antioxidant …