• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Abstract Aim The “2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management
of Patients With Chronic Coronary Disease” provides an update to and consolidates new …

Background Percutaneous coronary intervention (PCI) is frequently performed to reduce the
symptoms of stable angina. Whether PCI relieves angina more than a placebo procedure in …

Importance Recent clinical and imaging studies underscore that major adverse cardiac
events (MACE) outcomes are associated not solely with severe coronary obstructions …

Background: The ISCHEMIA trial (International Study of Comparative Health Effectiveness
With Medical and Invasive Approaches) compared an initial invasive versus an initial …

Understanding the natural history of coronary artery atherosclerosis is necessary to
determine prognosis and prescribe effective therapies. Traditional management of coronary …

The detection and characterization of coronary artery stenosis and atherosclerosis using
imaging tools are key for clinical decision-making in patients with known or suspected …

The pharmaceutical industry and its global regulators have routinely used frequentist
statistical methods, such as null hypothesis significance testing and p values, for evaluation …

Background Anatomic complete revascularization (ACR) and functional complete
revascularization (FCR) have been associated with reduced death and myocardial infarction …