Epstein-Barr virus (EBV) is a widespread human herpes virus associated with lymphomas
and epithelial cell cancers. It establishes two separate infection phases, latent and lytic, in …

Simple Summary The prognosis for patients with locoregionally advanced and metastatic
melanoma remains poor despite advances in systemic therapy. By delivering therapeutics …

Herpes simplex virus (HSV) protein immediate early-infected cell protein (ICP) 47 inhibits
the transporter associated with antigen presentation, thereby concealing infected cells from …

The antigen presentation molecule MR1 (major histocompatibility complex, class I–related)
presents ligands derived from the riboflavin (vitamin B) synthesis pathway, which is not …

A complete resection of tongue cancer is often difficult. We investigate the usefulness of
administering G47Δ (teserpaturev), a triple-mutated oncolytic herpes simplex virus type 1 …

Herpesviruses are large DNA viruses that have long been used as powerful gene therapy
tools. In recent years, the ability of herpesviruses to stimulate both innate and adaptive …

Background G47∆ is a triple-mutated oncolytic herpes simplex virus type 1 (HSV-1) recently
approved as a new drug for malignant glioma in Japan. As the next-generation, we develop …

Amongst the DNA viruses, the herpesvirus family has been perhaps the most extensively
studied in terms of genetics and pathogenesis, and will therefore be the primary focus for …