Pain-resolving immune mechanisms in neuropathic pain
Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …
Neuropathic pain: mechanisms, sex differences, and potential therapies for a global problem
S Ghazisaeidi, MM Muley… - Annual Review of …, 2023 - annualreviews.org
The study of chronic pain continues to generate ever-increasing numbers of publications,
but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex …
but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex …
Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function
M Jung, M Dourado, J Maksymetz, A Jacobson… - Nature …, 2023 - nature.com
Sensory neurons of the dorsal root ganglion (DRG) are critical for maintaining tissue
homeostasis by sensing and initiating responses to stimuli. While most preclinical studies of …
homeostasis by sensing and initiating responses to stimuli. While most preclinical studies of …
RNA profiling of human dorsal root ganglia reveals sex differences in mechanisms promoting neuropathic pain
Neuropathic pain is a leading cause of high-impact pain, is often disabling and is poorly
managed by current therapeutics. Here we focused on a unique group of neuropathic pain …
managed by current therapeutics. Here we focused on a unique group of neuropathic pain …
Neuropathic pain: From actual pharmacological treatments to new therapeutic horizons
M Thouaye, I Yalcin - Pharmacology & Therapeutics, 2023 - Elsevier
Neuropathic pain, caused by a lesion or disease affecting the somatosensory system, affects
between 3 and 17% of the general population. The treatment of neuropathic pain is …
between 3 and 17% of the general population. The treatment of neuropathic pain is …
Self-renewing macrophages in dorsal root ganglia contribute to promote nerve regeneration
R Feng, V Muraleedharan Saraswathy… - Proceedings of the …, 2023 - National Acad Sciences
Sensory neurons located in dorsal root ganglia (DRG) convey sensory information from
peripheral tissue to the brain. After peripheral nerve injury, sensory neurons switch to a …
peripheral tissue to the brain. After peripheral nerve injury, sensory neurons switch to a …
CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier
In dorsal root ganglia (DRG), macrophages reside close to sensory neurons and have
largely been explored in the context of pain, nerve injury, and repair. However, we …
largely been explored in the context of pain, nerve injury, and repair. However, we …
[HTML][HTML] Dermal macrophages set pain sensitivity by modulating the amount of tissue NGF through an SNX25–Nrf2 pathway
Cross-talk between peripheral neurons and immune cells is important in pain sensation. We
identified Snx25 as a pain-modulating gene in a transgenic mouse line with reduced pain …
identified Snx25 as a pain-modulating gene in a transgenic mouse line with reduced pain …
Neuron-associated macrophage proliferation in the sensory ganglia is associated with peripheral nerve injury-induced neuropathic pain involving CX3CR1 signaling
Resident macrophages are distributed across all tissues and are highly heterogeneous due
to adaptation to different tissue-specific environments. The resident macrophages of the …
to adaptation to different tissue-specific environments. The resident macrophages of the …
BDNF as a biomarker for neuropathic pain: Consideration of mechanisms of action and associated measurement challenges
B Thakkar, EO Acevedo - Brain and Behavior, 2023 - Wiley Online Library
Introduction The primary objective of this paper is to (1) provide a summary of human studies
that have used brain derived neurotrophic factor (BDNF) as a biomarker,(2) review animal …
that have used brain derived neurotrophic factor (BDNF) as a biomarker,(2) review animal …