Chronic pain relief remains an unmet medical need. Current research points to a substantial
contribution of glia-neuron interaction in its pathogenesis. Particularly, microglia play a …

Knowledge about the mechanisms of transmission and the processing of nociceptive
information, both in healthy and pathological states, has greatly expanded in recent years …

Microglia are important mediators of neuroinflammation, which underlies neuropathic pain.
However, the molecular checkpoints controlling microglial reactivity are not well-understood …

Chronic neuropathic pain (CNP) is a vast world health problem often associated with the
somatosensory domain. This conceptualization is problematic because, unlike most other …

Background Microglia has gradually gained researchers' attention in the past few decades
and has shown its promising prospect in treating neuropathic pain. Our study was performed …

Paclitaxel (PTX) is an anticancer drug used to treat solid tumors, but one of its common
adverse effects is chemotherapy-induced peripheral neuropathy (CIPN). Currently, there is …

Substance abuse is one of the significant problems in social and public health worldwide.
Vast numbers of evidence illustrate that motivational and reinforcing impacts of addictive …

Degenerative diseases affect people's life and health and cause a severe social burden.
Relevant mechanisms of microglia have been studied, aiming to control and reduce …

Migraine is a complex and debilitating neurological disease that affects 15% of the
population worldwide. It is defined by the presence of recurrent severe attacks of disabling …

Microglia activation in the spinal cord play a major role in the pathogenesis of neuropathic
pain. The p38 mitogen-activated protein kinase (MAPK) regulates microglia activation …