Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis
as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still …

During oncogenesis, cancer not only escapes the body's regulatory mechanisms, but also
gains the ability to affect local and systemic homeostasis. Specifically, tumors produce …

Lung cancer is the leading cause of cancer-associated mortality worldwide. Here we
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 …

In this opinion, we highlight agent-based modeling as a key tool for exploration of cell–cell
and cell–environment interactions that drive cancer progression, therapeutic resistance, and …

Background Although metastasis is the foremost cause of cancer-related death, a
specialized mechanism that reprograms anchorage dependency of solid tumor cells into …

Disseminated tumor cells with metabolic flexibility to utilize available nutrients in distal
organs persist, but the precise mechanisms that facilitate metabolic adaptations remain …

Due to increasing incidence and limited treatments, brain metastases (BM) are an emerging
unmet need in modern oncology. Development of effective therapeutics has been hindered …

Metastasis is a complex process and the leading cause of cancer-related death globally.
Recent studies have demonstrated that genomic sequencing data from paired primary and …

Cancer and its metastases arise from mutations of genes, drivers that promote a tumor's
growth. Analyses of driver events provide insights into cancer cell history and may lead to a …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers,
associated with poor survival outcomes. Lack of early diagnosis, resistance to conventional …