2022 update on prostate cancer epidemiology and risk factors—a systematic review
O Bergengren, KR Pekala, K Matsoukas, J Fainberg… - European urology, 2023 - Elsevier
Abstract Context Prostate cancer (PCa) is one of the most common cancers worldwide.
Understanding the epidemiology and risk factors of the disease is paramount to improve …
Understanding the epidemiology and risk factors of the disease is paramount to improve …
Polygenic scores in cancer
Since the publication of the first genome-wide association study for cancer in 2007,
thousands of common alleles that are associated with the risk of cancer have been …
thousands of common alleles that are associated with the risk of cancer have been …
[HTML][HTML] Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study
Y Long, L Tang, Y Zhou, S Zhao, H Zhu - BMC medicine, 2023 - Springer
Background Evidence from observational studies and clinical trials suggests that the gut
microbiota is associated with cancer. However, the causal association between gut …
microbiota is associated with cancer. However, the causal association between gut …
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries
Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-
wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of …
wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of …
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
The transferability and clinical value of genetic risk scores (GRSs) across populations
remain limited due to an imbalance in genetic studies across ancestrally diverse …
remain limited due to an imbalance in genetic studies across ancestrally diverse …
[HTML][HTML] Mendelian randomization and clinical trial evidence supports TYK2 inhibition as a therapeutic target for autoimmune diseases
Background To explore the associations of genetically proxied TYK2 inhibition with a wide
range of disease outcomes and biomarkers to identify therapeutic repurposing opportunities …
range of disease outcomes and biomarkers to identify therapeutic repurposing opportunities …
Gut microbiota and risk of five common cancers: A univariable and multivariable Mendelian randomization study
Z Wei, B Yang, T Tang, Z Xiao, F Ye, X Li… - Cancer …, 2023 - Wiley Online Library
Background Previous studies have linked gut microbiota with cancer etiology, but the
associations for specific gut microbiota are causal or owing to bias remain to be elucidated …
associations for specific gut microbiota are causal or owing to bias remain to be elucidated …
[HTML][HTML] Recurrent repeat expansions in human cancer genomes
Expansion of a single repetitive DNA sequence, termed a tandem repeat (TR), is known to
cause more than 50 diseases,. However, repeat expansions are often not explored beyond …
cause more than 50 diseases,. However, repeat expansions are often not explored beyond …
Genetic risk prediction for prostate cancer: implications for early detection and prevention
Abstract Context Prostate cancer (PCa) is a leading cause of death and partially heritable.
Genetic risk prediction might be useful for strategies to reduce PCa mortality through early …
Genetic risk prediction might be useful for strategies to reduce PCa mortality through early …
Evidence of novel susceptibility variants for prostate cancer and a multiancestry polygenic risk score associated with aggressive disease in men of African ancestry
Background Genetic factors play an important role in prostate cancer (PCa) susceptibility.
Objective To discover common genetic variants contributing to the risk of PCa in men of …
Objective To discover common genetic variants contributing to the risk of PCa in men of …