Molecular mechanisms of ferroptosis and relevance to inflammation

L Deng, S He, N Guo, W Tian, W Zhang, L Luo - Inflammation Research, 2023 - Springer
Introduction Inflammation is a defensive response of the organism to irritation which is
manifested by redness, swelling, heat, pain and dysfunction. The inflammatory response …

Food polyphenols and type II diabetes mellitus: pharmacology and mechanisms

R Naz, F Saqib, S Awadallah, M Wahid, MF Latif, I Iqbal… - Molecules, 2023 - mdpi.com
Type II diabetes mellitus and its related complications are growing public health problems.
Many natural products present in our diet, including polyphenols, can be used in treating …

Hesperetin attenuates sepsis-induced intestinal barrier injury by regulating neutrophil extracellular trap formation via the ROS/autophagy signaling pathway

F Chen, C Chu, X Wang, C Yang, Y Deng, Z Duan… - Food & function, 2023 - pubs.rsc.org
Background: Hesperetin (HES), one of the major flavonoids that has various biological
activities, such as anti-inflammatory and antioxidant activities, may preserve the intestinal …

Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway

S Liu, X Gao, Y Yin, J Wang, K Dong, D Shi… - Food and Chemical …, 2023 - Elsevier
Silk fibroin (SF) has excellent biocompatibility and biodegradability as a biomaterial. The
purity and molecular weight distribution of silk fibroin peptide (SFP) make it more suitable for …

Flavonoids of Haloxylon salicornicum (Rimth) prevent cisplatin-induced acute kidney injury by modulating oxidative stress, inflammation, Nrf2, and SIRT1

SA Ramadan, EM Kamel, MA Ewais… - … Science and Pollution …, 2023 - Springer
Cisplatin (CIS) is an effective chemotherapeutic drug used for the treatment of many types of
cancers, but its use is associated with adverse effects. Nephrotoxicity is a serious side effect …

Hesperetin and capecitabine abate 1, 2 dimethylhydrazine-induced colon carcinogenesis in wistar rats via suppressing oxidative stress and enhancing antioxidant …

AK Hassan, AM El-Kalaawy, SM Abd El-Twab… - Life, 2023 - mdpi.com
Colon cancer is a major cause of cancer-related death, with significantly increasing rates of
incidence worldwide. The current study was designed to evaluate the anti-carcinogenic …

Antioxidant, Antiapoptotic, and Anti-Inflammatory Effects of Hesperetin in a Mouse Model of Lipopolysaccharide-Induced Acute Kidney Injury

AY Yang, HJ Choi, K Kim, J Leem - Molecules, 2023 - mdpi.com
Sepsis is a severe inflammatory condition that can cause organ dysfunction, including acute
kidney injury (AKI). Hesperetin is a flavonoid aglycone that has potent antioxidant and anti …

Protective effects of pomegranate (Punica granatum) and its main components against natural and chemical toxic agents: A comprehensive review

A Hosseini, BM Razavi, H Hosseinzadeh - Phytomedicine, 2023 - Elsevier
Background Different chemical toxicants or natural toxins can damage human health
through various routes such as air, water, fruits, foods, and vegetables. Purpose Herbal …

Peroxynitrite activated near-infrared fluorescent probe for evaluating ferroptosis-mediated acute kidney injury

W Yang, R Liu, X Yin, Y Jin, L Wang, M Dong… - Sensors and Actuators B …, 2023 - Elsevier
Ferroptosis is a form of programmed cell death mostly characterized by a serious
misadjustment in the production and degradation of lipid reactive oxygen species (ROS) …

Fabrication of a citrus flavonoid hesperetin-capped gold nanoparticles-reduced graphene oxide nanocomposites (Hes-Au/rGONCs) as a potential therapeutic agent …

PK Seetharaman, A Sivapunniyam, P Ramalingam… - Surfaces and …, 2023 - Elsevier
Abstract Hesperetin (Hes) is a Citrus Flavonoid, which is confirmed to have extensive
therapeutic effects, comprising antimicrobial, antioxidant, anticancer, cardiovascular …