In the last decades, the advancement of knowledge in analgesia and sedation for critically ill
pediatric patients has been conspicuous and relevant. Many recommendations have …

Studies have clearly shown that development of pain receptors starts as early as 20-weeks'
gestation. Despite contrary belief, the human fetus develops a similar number of receptive …

Acetaminophen is one of the oldest medications commonly administered in children. Its
efficacy in treating fever and pain is well accepted among clinicians. However, the available …

ABSTRACT Introduction Pharmacokinetic (PK)-Pharmacodynamic (PD) and exposure-
response (ER) modeling are critical parts of pediatric drug development. By integrating …

Background Neonates may undergo surgery because of malformations such as
diaphragmatic hernia, gastroschisis, congenital heart disease, and hypertrophic pyloric …

Aims To investigate the pharmacokinetics and safety of prolonged paracetamol use (> 72 h)
for neonatal pain. Methods Neonates were included if they received paracetamol orally or …

Background The need for pain management is increasing in pediatrics, but the side effects
of overuse or abuse of analgesics can be harmful to children's health and even life …

Objective The aim of this study was to describe the use, duration, and intercenter variation of
analgesia and sedation in infants with congenital diaphragmatic hernia (CDH). Study …

由于新生儿自身的发育生理和药代动力学特点, 临床上针对这一人群的术后镇痛仍然受到一定
程度的限制. 新生儿尤其是早产儿仅被提供最少甚至不进行麻醉和镇痛. 随着对生理学的深入 …

Background Acetaminophen is routinely used for perioperative analgesia in children
undergoing major surgical procedures. There are few estimates of acetaminophen …