ABSTRACT p53 (also known as TP53) mutation and amyloid formation are long associated
with cancer pathogenesis; however, the direct demonstration of the link between p53 …

Amyloids are high-order proteinaceous formations deposited in both intra-and extracellular
spaces. These aggregates have tendencies to deregulate cellular physiology in multiple …

The transcription factor p53 suppresses tumorigenesis via a wide-ranging, concerted set of
functions. Although several studies have identified cytoplasmic, transcription-independent …

Abstract The PI3K/AKT and p53 pathways are key regulators of cancer cell survival and
death, respectively. Contrary to their generally accepted roles, several lines of evidence …

Background HeberFERON is a co-formulation of α2b and γ interferons, based on their
synergism, which has shown its clinical superiority over individual interferons in basal cell …

Phase separation of various transcription factors and nucleic acids into biomolecular
condensates is known to play an essential role in the regulation of gene expression. Here …

p53 mutation and amyloid formation are implicated with cancer pathogenesis, but the direct
demonstration of the link between p53 amyloid load and cancer progression is lacking …

Loss or improper regulation of p53 plays a role in the progression of most human cancers.
Understanding the molecular mechanisms that mediate the regulation and activity of p53 …