Innate immune responses in pneumonia

FT Korkmaz, KE Traber - Pneumonia, 2023 - Springer
The lungs are an immunologically unique environment; they are exposed to innumerable
pathogens and particulate matter daily. Appropriate clearance of pathogens and response to …

Interkingdom detection of bacterial quorum-sensing molecules by mammalian taste receptors

YI Kouakou, RJ Lee - Microorganisms, 2023 - mdpi.com
Bitter and sweet taste G protein-coupled receptors (known as T2Rs and T1Rs, respectively)
were originally identified in type II taste cells on the tongue, where they signal perception of …

Actuation-enhanced multifunctional sensing and information recognition by magnetic artificial cilia arrays

J Han, X Dong, Z Yin, S Zhang, M Li… - Proceedings of the …, 2023 - National Acad Sciences
Artificial cilia integrating both actuation and sensing functions allow simultaneously sensing
environmental properties and manipulating fluids in situ, which are promising for …

A singular shark bitter taste receptor provides insights into the evolution of bitter taste perception

M Behrens, T Lang… - Proceedings of the …, 2023 - National Acad Sciences
Many animal and plant species synthesize toxic compounds as deterrent; thus, detection of
these compounds is of vital importance to avoid their ingestion. Often, such compounds are …

Physiological activation of human and mouse bitter taste receptors by bile acids

F Ziegler, A Steuer, A Di Pizio, M Behrens - Communications Biology, 2023 - nature.com
Beside the oral cavity, bitter taste receptors are expressed in several non-gustatory tissues.
Whether extra-oral bitter taste receptors function as sensors for endogenous agonists is …

Loss of CFTR function is associated with reduced bitter taste receptor-stimulated nitric oxide innate immune responses in nasal epithelial cells and macrophages

RM Carey, JN Palmer, ND Adappa, RJ Lee - Frontiers in Immunology, 2023 - frontiersin.org
Introduction Bitter taste receptors (T2Rs) are G protein-coupled receptors identified on the
tongue but expressed all over the body, including in airway cilia and macrophages, where …

[HTML][HTML] CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection

AE Prendergast, KK Jim, H Marnas, L Desban… - Current Biology, 2023 - cell.com
The pathogenic bacterium Streptococcus pneumoniae (S. pneumoniae) can invade the
cerebrospinal fluid (CSF) and cause meningitis with devastating consequences. Whether …

Chemosensory cells in the respiratory tract as crucial regulators of innate immune responses

MI Hollenhorst, G Krasteva‐Christ - The Journal of Physiology, 2023 - Wiley Online Library
During recent years chemosensory cells in extraoral tissues have been established as
mediators for the detection and regulation of innate immune processes in response to …

Cilia and cancer: From molecular genetics to therapeutic strategies

P Carotenuto, SA Gradilone, B Franco - Genes, 2023 - mdpi.com
Cilia are microtubule-based organelles that project from the cell surface with motility or
sensory functions. Primary cilia work as antennae to sense and transduce extracellular …

Computational analysis of cilia-mediated flow dynamics of Jeffrey nanofluid in physiologically realistic geometries

M Ijaz Khan, A Abbasi, S Danish, W Farooq - Physics of Fluids, 2023 - pubs.aip.org
Cilia play important roles in fluid transport and development by propagating metachronal
waves along cell surfaces. This study numerically investigates the biomechanics of cilia …