A series of 12 S‐substituted tetrahydrobenzothienopyrimidines were designed and
synthesized based on the donepezil scaffold. All the newly synthesized compounds were …

Alzheimer's disease (AD) is one of the most prevalent geriatric diseases and a significant
cause of high mortality. This crippling disorder is becoming more prevalent at an …

Enzyme biocatalysis is reshaping pharmaceutical synthesis, offering sustainable and
efficient pathways for drug discovery and production. This paradigm shift towards eco …

Background: Alzheimer's disease is a neurological disorder that causes brain cells to shrink
and die. Aim: Thirteen novel 'oxathiolanyl','pyrazolyl'and 'pyrimidinyl'indole derivatives were …

Objective: The study was conducted to evaluate the in vitro acetylcholinesterase (AchE)
inhibition activity of novel pyrano [2, 3-d] pyrimidine derivatives. Methods: A series of new …

Alzheimer's disease (AD), an ongoing neurodegenerative disorder among the elderly, is
signalized by amnesia, progressive deficiency in cognitive roles, and behavioral deformity …

Butyrylcholinesterase (BuChE) is an enzyme implicated in Alzheimer's disease due to the
excessive breakdown of neurotransmitters. The study screened and synthesized de novo …

Acetylcholinesterase is used as a key target in the treatment of Alzheimer's disease.
Recently, a series of new spirooxindolepyrrolidine derivatives were synthesized and …

A novel series of benzo [cd] indol-2 (1H)-one-donepezil (BIO-DPZ) hybrids (5a-m, 6a-k) was
designed, synthesized and evaluated as cholinesterase inhibitors and living cell imaging …

A set of novel β-carboline derivatives were designed and subjected to virtual screening
studies by molecular docking in AChE. Among the compounds investigated, derivatives 1a …