Less is more: Antibiotics at the beginning of life

M Stocker, C Klingenberg, L Navér, V Nordberg… - Nature …, 2023 - nature.com
Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance
and perturbations of the developing microbiome. Early-life microbiome disruption increases …

Migraine: from pathophysiology to treatment

F Puledda, EM Silva, K Suwanlaong, PJ Goadsby - Journal of Neurology, 2023 - Springer
Migraine is an extremely disabling, common neurological disorder characterized by a
complex neurobiology, involving a series of central and peripheral nervous system areas …

Molecular dynamics and multi-spectroscopic of the interaction behavior between bladder cancer cells and calf thymus DNA with rebeccamycin: apoptosis through the …

Z Malek-Esfandiari, A Rezvani-Noghani, T Sohrabi… - Journal of …, 2023 - Springer
The interaction of Rebeccamycin with calf thymus (ctDNA) in the absence and presence of
H1 was investigated by molecular dynamics, multi-spectroscopic, and cellular techniques …

2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension

M Humbert, G Kovacs, MM Hoeper… - European …, 2023 - Eur Respiratory Soc
Guidelines summarize and evaluate available evidence, with the aim of assisting health
professionals in proposing the best management strategies for an individual patient with a …

Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence

Y Wu, L Tang, H Huang, Q Yu, B Hu, G Wang… - Nature …, 2023 - nature.com
Vascular endothelial cells (ECs) senescence correlates with the increase of cardiovascular
diseases in ageing population. Although ECs rely on glycolysis for energy production, little is …

Fear circuit–based neurobehavioral signatures mirror resilience to chronic social stress in mouse

S Ayash, T Lingner, A Ramisch, S Ryu… - Proceedings of the …, 2023 - National Acad Sciences
Consistent evidence from human data points to successful threat–safety discrimination and
responsiveness to extinction of fear memories as key characteristics of resilient individuals …

Global, regional, and national HIV/AIDS disease burden levels and trends in 1990–2019: a systematic analysis for the global burden of disease 2019 study

X Tian, J Chen, X Wang, Y Xie, X Zhang… - Frontiers in Public …, 2023 - frontiersin.org
Background Since the first HIV/AIDS case appeared in 1980s, HIV/AIDS has been the focus
of international attention. As a major public health problem, there are epidemiological …

Needs and well-being across Europe: Basic psychological needs are closely connected with well-being, meaning, and symptoms of depression in 27 European …

F Martela, A Lehmus-Sun, PD Parker… - Social …, 2023 - journals.sagepub.com
In the quest to identify the key sources of subjective well-being, self-determination theory
(SDT) has proposed that three basic psychological needs—autonomy, competence, and …

The global, regional, and national burden of appendicitis in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study …

L Guan, Z Liu, G Pan, B Zhang, Y Wu, T Gan… - BMC …, 2023 - Springer
Background Appendicitis is the most common abdominal surgical emergency worldwide,
and its burden has been changing. We report the level and trends of appendicitis …

Revised FDI criteria for evaluating direct and indirect dental restorations—recommendations for its clinical use, interpretation, and reporting

R Hickel, S Mesinger, N Opdam, B Loomans… - Clinical oral …, 2023 - Springer
Objectives The FDI criteria for the evaluation of direct and indirect dental restorations were
first published in 2007 and updated in 2010. Meanwhile, their scientific use increased …