Cell death is critical for the development and homeostasis of almost all multicellular
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …

Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …

Cell death and inflammation are closely linked arms of the innate immune response to
combat infection and tissue malfunction. Recent advancements in our understanding of the …

The dependency of cancer cells on iron increases their susceptibility to ferroptosis, thus
providing new opportunities for patients with treatment-resistant tumors. However, we show …

Although anion channel activities have been demonstrated in sarcoplasmic
reticulum/endoplasmic reticulum (SR/ER), their molecular identities and functions remain …

Rationale: Sepsis is a potentially life-threatening condition caused by the body's response to
a severe infection. Although the identification of multiple pathways involved in inflammation …

Globally, brucellosis is a widespread zoonotic disease. It is prevalent in more than 170
countries and regions. It mostly damages an animal's reproductive system and causes …

Significance: Autophagy is critical to cellular homeostasis. Emergence of the concept of
regulated necrosis, such as necroptosis, ferroptosis, pyroptosis, and mitochondrial …

Receptor-interacting serine/threonine kinase 2 (RIPK2) is a vital immunomodulator that
plays critical roles in nucleotide-binding oligomerization domain 1 (NOD1), NOD2, and Toll …

Epidemiological evidence supports an association between cow's milk consumption and the
risk of diffuse large B-cell lymphoma (DLBCL), the most common non-Hodgkin lymphoma …