Autophagy is the process by which cells degrade and recycle proteins and organelles to
maintain intracellular homeostasis. Generally, autophagy plays a protective role in cells, but …

Simple Summary The metabolism of carbohydrates and lipids is essential to meet the
diverse needs of cells. The autophagy cellular pathway is crucial for normal cellular function …

In this review article, we embark on a thorough exploration of cannabinoids, compounds that
have garnered considerable attention for their potential therapeutic applications. Initially, this …

Abstract Dihydroceramide desaturase 1 (DEGS1) converts dihydroceramide (dhCer) to
ceramide (Cer) by inserting a C4-C5 trans (∆ 4E) double bond into the sphingoid backbone …

The Covid-19 pandemic driven by the SARS-CoV-2 virus continues to exert extensive
humanitarian and economic stress across the world. Although antivirals active against mild …

Despite the extensive efforts to find effective therapeutic strategies, glioblastoma (GBM)
remains a therapeutic challenge with dismal prognosis of survival. Over the last decade the …

Specific membrane lipids play unique roles in (macro) autophagy. Those include
phosphatidylethanolamine, to which LC3/GABARAP autophagy proteins become covalently …

The endoplasmic reticulum (ER) organelle is the key intracellular site of both protein and
lipid biosynthesis. ER dysfunction, termed ER stress, can result in protein accretion within …

Sphingolipids are a diverse family of complex lipids typically composed of a sphingoid base
bound to a fatty acid via amide bond. The metabolism of sphingolipids has long remained …

Abstract Δ 9-tetrahydrocannabinol (THC), cannabidiol (CBD) and other natural compounds
produced by Cannabis sativa exhibit a wide array of therapeutic effects on the human body …