It is almost a century since nisin was discovered in fermented milk cultures, coincidentally in
the same year that penicillin was first described. Over the last 100 years this small, highly …

Peptides are biopolymers, typically consisting of 2–50 amino acids. They are biologically
produced by the cellular ribosomal machinery or by non-ribosomal enzymes and …

The tetrazine ligation is an inverse electron-demand Diels–Alder reaction widely used for
bioorthogonal modifications due to its versatility, site specificity and fast reaction kinetics. A …

Abstract Cihunamides A–D (1–4), novel antibacterial RiPPs, were isolated from volcanic‐
island‐derived Streptomyces sp. The structures of 1–4 were elucidated by 1H, 13C, and 15N …

The domain of unknown function 692 (DUF692) is an emerging family of post-translational
modification enzymes involved in the biosynthesis of ribosomally synthesized and post …

Ribosomally synthesized and post-translationally modified peptide natural products have
provided many highly unusual scaffolds. This includes the intriguing alkaloids crocagins …

Terpenoids, also known as isoprenoids, are the largest and most diverse class of organic
compounds in nature and are involved in many membrane-associated cellular processes …

The ability to manipulate the chemical composition of proteins and peptides has been
central to the development of improved polypeptide-based therapeutics and has enabled …

Despite their remarkable biosynthetic potential, Bacillus subtilis have been widely
overlooked. However, their capability to withstand harsh conditions (extreme temperature …

Lantibiotics are ribosomally synthesized and posttranslationally modified peptides (RiPPs)
that are produced by bacteria. Interest in this group of natural products is increasing rapidly …