The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Alternative splicing (AS) of RNA molecules is a key contributor to transcriptome diversity. In
humans, 90%–95% of multi-exon genes produce alternatively spliced RNA transcripts …

Glioblastoma (GBM) ranks among the most lethal of human cancers, containing glioma stem
cells (GSCs) that display therapeutic resistance. Here, we report that the lncRNA INHEG is …

Sunitinib resistance remains a serious challenge to the treatment of advanced and
metastatic renal cell carcinoma (RCC), yet the mechanisms underlying this resistance are …

Nasopharyngeal carcinoma (NPC) is a common head and neck malignant with a high
incidence in Southern China. Genetic aberrations play a vital role in the pathogenesis …

Transposable elements hold regulatory functions that impact cell fate determination by
controlling gene expression. However, little is known about the transcriptional machinery …

The burden of human disease lies predominantly in polygenic diseases. Since the early
2000s, genome-wide association studies (GWAS) have identified genetic variants and loci …

Cancer is driven by both germline and somatic genetic changes. Efforts have been devoted
to characterizing essential genetic variations in cancer initiation and development. Most …

Genetic sharing is extensively observed for autoimmune diseases, but the causal variants
and their underlying molecular mechanisms remain largely unknown. Through systematic …

Renal cell carcinoma (RCC) is a common urological malignancy and represents a leading
threat to healthcare. Recent years have seen a series of progresses in the early diagnosis …