Hepatocellular carcinoma surveillance—Utilization, barriers and the impact of changing aetiology

DQ Huang, AG Singal, F Kanwal… - Nature Reviews …, 2023 - nature.com
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide.
Surveillance for HCC is critical for early detection and treatment, but fewer than one-quarter …

Diagnosis and management of autoimmune hepatitis

L Muratori, AW Lohse, M Lenzi - bmj, 2023 - bmj.com
Autoimmune hepatitis is an inflammatory disease of the liver of unknown cause that may
progress to liver cirrhosis and end stage liver failure if diagnosis is overlooked and treatment …

AASLD practice guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma

AG Singal, JM Llovet, M Yarchoan, N Mehta… - Hepatology, 2023 - journals.lww.com
This guidance document provides an updated approach to the prevention, diagnosis, and
treatment of hepatocellular carcinoma (HCC). The prior American Association for the Study …

Lenvatinib combined with transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma: a phase III, randomized clinical trial …

Z Peng, W Fan, B Zhu, G Wang, J Sun… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE Lenvatinib (LEN) is a first-line therapy for patients with advanced hepatocellular
carcinoma (HCC); however, it has shown modest survival benefits. Therefore, we aimed to …

AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma

CL Bowlus, L Arrivé, A Bergquist, M Deneau… - Hepatology, 2023 - journals.lww.com
Abbreviations: AASLD, American Association for the Study of Liver Diseases; AIH,
autoimmune hepatitis; ALP, alkaline phosphatase; ASIR, age standardized incidence rate; …

A multidisciplinary approach to the diagnosis and management of Wilson disease: Executive summary of the 2022 Practice Guidance on Wilson disease from the …

ML Schilsky, EA Roberts, JM Bronstein, A Dhawan… - Hepatology, 2023 - journals.lww.com
Copper is an essential metal required for many metalloproteins' function. A fraction of dietary
copper (average 2–5 mg/day) is absorbed by enterocytes in the duodenum and proximal …

Detecting liver cancer using cell-free DNA fragmentomes

ZH Foda, AV Annapragada, K Boyapati, DC Bruhm… - Cancer discovery, 2023 - AACR
Liver cancer is a major cause of cancer mortality worldwide. Screening individuals at high
risk, including those with cirrhosis and viral hepatitis, provides an avenue for improved …

Eliminating METTL1‐mediated accumulation of PMN‐MDSCs prevents hepatocellular carcinoma recurrence after radiofrequency ablation

X Zeng, G Liao, S Li, H Liu, X Zhao, S Li, K Lei… - Hepatology, 2023 - journals.lww.com
Conclusions: Our study sheds light on the pivotal role of METTL1 in modulating an
immunosuppressive microenvironment and demonstrated that interrupting METTL1‐TGF‐β2 …

[HTML][HTML] Chronic liver disease

A Sharma, S Nagalli - StatPearls [Internet], 2023 - ncbi.nlm.nih.gov
Objectives: Identify the etiology of chronic liver disease. Outline the appropriate evaluation of
chronic liver disease. Review the treatment options available for chronic liver disease …

[HTML][HTML] Immunotherapy for hepatocellular carcinoma: Current status and future perspectives

DS Mandlik, SK Mandlik… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the world's deadliest and fastest-growing tumors,
with a poor prognosis. HCC develops in the context of chronic liver disease. Curative …