Autonomic nervous system and cardiac neuro-signaling pathway modulation in cardiovascular disorders and Alzheimer's disease

A Elia, S Fossati - Frontiers in Physiology, 2023 - frontiersin.org
The heart is a functional syncytium controlled by a delicate and sophisticated balance
ensured by the tight coordination of its several cell subpopulations. Accordingly …

What makes the sinoatrial node tick? A question not for the faint of heart

L Donald, EG Lakatta - Philosophical Transactions of the …, 2023 - royalsocietypublishing.org
Even before the sinoatrial node (SAN) was discovered, cardiovascular science was
engaged in an active investigation of when and why the heart would beat. After the …

Vagal nerve stimulation reduces ventricular arrhythmias and mitigates adverse neural cardiac remodeling post–myocardial infarction

J Hadaya, AH Dajani, S Cha, P Hanna… - Basic to Translational …, 2023 - jacc.org
This study sought to evaluate the impact of chronic vagal nerve stimulation (cVNS) on
cardiac and extracardiac neural structure/function after myocardial infarction (MI). Groups …

Overview of cardiac arrhythmias and treatment strategies

J Kingma, C Simard, B Drolet - Pharmaceuticals, 2023 - mdpi.com
Maintenance of normal cardiac rhythm requires coordinated activity of ion channels and
transporters that allow well-ordered propagation of electrical impulses across the …

Magnetic vagus nerve stimulation alleviates myocardial ischemia-reperfusion injury by the inhibition of pyroptosis through the M2AChR/OGDHL/ROS axis in rats

Y Lu, K Chen, W Zhao, Y Hua, S Bao, J Zhang… - Journal of …, 2023 - Springer
Background Myocardial ischemia-reperfusion (I/R) injury is accompanied by an imbalance
in the cardiac autonomic nervous system, characterized by over-activated sympathetic tone …

Tiered sympathetic control of cardiac function revealed by viral tracing and single cell transcriptome profiling

S Sharma, R Littman, JD Tompkins, D Arneson… - Elife, 2023 - elifesciences.org
The cell bodies of postganglionic sympathetic neurons innervating the heart primarily reside
in the stellate ganglion (SG), alongside neurons innervating other organs and tissues …

Exercise in treatment-resistant hypertension. A natural neuromodulation therapy?

M Nagai, CY Förster - Hypertension Research, 2023 - nature.com
Current guidelines recommend adopting lifestyle changes as the first line of therapy to
manage hypertension [1]. In particular, a large body of evidence supports the …

Catecholaminergic axon innervation and morphology in flat‐mounts of atria and ventricles of mice

A Bizanti, Y Zhang, SW Harden, J Chen… - Journal of …, 2023 - Wiley Online Library
Sympathetic efferent axons regulate cardiac functions. However, the topographical
distribution and morphology of cardiac sympathetic efferent axons remain insufficiently …

Cardiac innervations in diabetes mellitus—Anatomical evidence of neuropathy

N Filipović, M Marinović Guić, V Košta… - The Anatomical …, 2023 - Wiley Online Library
The extensive innervations of the heart include a complex network of sympathetic,
parasympathetic, and sensory nerves connected in loops that serve to regulate cardiac …

Mapping of neuro-cardiac electrophysiology: Interlinking epilepsy and arrhythmia

SG Senapati, AK Bhanushali, S Lahori… - Journal of …, 2023 - mdpi.com
The interplay between neurology and cardiology has gained significant attention in recent
years, particularly regarding the shared pathophysiological mechanisms and clinical …