Methods and insights from single-cell expression quantitative trait loci
Recent advancements in single-cell technologies have enabled expression quantitative trait
locus (eQTL) analysis across many individuals at single-cell resolution. Compared with bulk …
locus (eQTL) analysis across many individuals at single-cell resolution. Compared with bulk …
[HTML][HTML] An integrated cell atlas of the lung in health and disease
Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions …
typically capture only a limited number of donors and disagree on cell type definitions …
[HTML][HTML] Spatial multiomics map of trophoblast development in early pregnancy
A Arutyunyan, K Roberts, K Troulé, FCK Wong… - Nature, 2023 - nature.com
The relationship between the human placenta—the extraembryonic organ made by the
fetus, and the decidua—the mucosal layer of the uterus, is essential to nurture and protect …
fetus, and the decidua—the mucosal layer of the uterus, is essential to nurture and protect …
An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia
Acute myeloid leukemia (AML) is a hematopoietic malignancy with poor prognosis and
limited treatment options. Here we provide a comprehensive census of the bone marrow …
limited treatment options. Here we provide a comprehensive census of the bone marrow …
[HTML][HTML] Spatially resolved multiomics of human cardiac niches
The function of a cell is defined by its intrinsic characteristics and its niche: the tissue
microenvironment in which it dwells. Here we combine single-cell and spatial …
microenvironment in which it dwells. Here we combine single-cell and spatial …
[PDF][PDF] A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids
The broad research use of organoids from high-grade serous ovarian cancer (HGSC) has
been hampered by low culture success rates and limited availability of fresh tumor material …
been hampered by low culture success rates and limited availability of fresh tumor material …
Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk
Recent advances in human blastoids have opened new avenues for modeling early human
development and implantation. One limitation of our first protocol for human blastoid …
development and implantation. One limitation of our first protocol for human blastoid …
Standardization and interpretation of RNA-sequencing for transplantation
Abstract RNA-sequencing (RNA-seq) is a technique to determine the order of nucleotides in
an RNA segment. Modern sequencing platforms simultaneously sequence millions of RNA …
an RNA segment. Modern sequencing platforms simultaneously sequence millions of RNA …
[HTML][HTML] Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+ GZMB− CD8+ memory T cells and accumulation of type 2 memory T cells
M Terekhova, A Swain, P Bohacova, E Aladyeva… - Immunity, 2023 - Elsevier
Extensive, large-scale single-cell profiling of healthy human blood at different ages is one of
the critical pending tasks required to establish a framework for the systematic understanding …
the critical pending tasks required to establish a framework for the systematic understanding …
[HTML][HTML] Cryobiopsy: a breakthrough strategy for clinical utilization of lung cancer organoids
One major challenge associated with lung cancer organoids (LCOs) is their predominant
derivation from surgical specimens of patients with early-stage lung cancer. However …
derivation from surgical specimens of patients with early-stage lung cancer. However …