Platelets are small, anucleate entities that bud from megakaryocytes in the bone marrow.
Among circulating cells, platelets are the most abundant cell, traditionally involved in …

Thrombosis remains a major problem in our society, manifesting across multiple
demographic groups and with high associated morbidity and mortality. Thrombus …

Antiplatelet medication is standard of care in acute myocardial infarction (AMI). However, it
may have obscured beneficial properties of the activated platelet secretome. We identify …

As 2023 approaches, the COVID-19 pandemic has killed millions. While vaccines have
been a crucial intervention, only a few effective medications exist for prevention and …

Abstract Purpose of Review The intricate interplay between inflammatory and reparative
responses in the context of heart injury is central to the pathogenesis of heart failure. Recent …

Heart failure (HF) with preserved ejection fraction (HFpEF) is associated with high burden of
comorbidities known to increase the mean platelet volume (MPV). This parameter has been …

Transforming growth factor-β1 (TGFβ1) is the key profibrotic cytokine in idiopathic pulmonary
fibrosis (IPF), but the primary source of this cytokine in this disease is unknown. Platelets …

SIRT3 is a longevity factor that acts as the primary deacetylase in mitochondria. Although
ubiquitously expressed, previous global SIRT3 knockout studies have shown primarily a …

Background Chronic thromboinflammation provokes microvascular alterations and
rarefaction, promoting organ dysfunction in individuals with various life-threatening …

Diabetes mellitus (DM) is on the rise, necessitating the development of novel therapeutic
and preventive strategies to mitigate the disease's debilitating effects. Diabetic …