Regulatory T cells (Treg cells) are key players in ensuring a peaceful coexistence with
microorganisms and food antigens at intestinal borders. Startling new information has …

Colorectal cancer (CRC) is the second most common cause of cancer mortality, with
mismatch repair proficient (pMMR) and/or microsatellite stable (MSS) CRC making up more …

Objective T cells are major effectors of the antitumoural immune response. Their activation
by tumour-associated antigens can unleash their proliferation and cytotoxic functions …

Simple Summary Chronic inflammation plays a significant role in colorectal cancer (CRC)
development, particularly in colitis-associated CRC (CAC). This study examined immune …

Background Multiple sclerosis (MS) is an aggressive disease characterized by central
nervous system (CNS) inflammatory and demyelinating lesions. Tolerance failure is …

Gastrointestinal (GI) cancers are a group of malignancies that globally account for a
significant portion of cancer incidence and cancer-related death. Survival outcomes for …

When antigenic tumor cells contact the immune system, they set off both innate and adaptive
immune system. In the previous chapter, we have described the host innate immune system …

Background: Systemic immunoglobulin light chain amyloidosis (AL amyloidosis) is a rare
plasma cell dyscrasia with a poor prognosis. T-cell exhaustion can lead to impaired T cell …

T cell exhaustion occurs when T cells are engaged by persistent antigen in the context of
chronic infection and cancer. The formation of the exhaustion phenotype severely limits T …

Immun-Checkpoint-Rezeptoren sind entscheidende Regulatoren des Immunsystems,
insbesondere bei Autoimmun-und Krebserkrankungen. Programmed Death 1 (PD-1) ist …