Chemokines and chemokine receptors as promising targets in rheumatoid arthritis

MA Murayama, J Shimizu, C Miyabe, K Yudo… - Frontiers in …, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease that commonly causes inflammation
and bone destruction in multiple joints. Inflammatory cytokines, such as IL-6 and TNF-α, play …

Crosstalk between fibroblasts and T cells in immune networks

B Lee, SH Lee, K Shin - Frontiers in Immunology, 2023 - frontiersin.org
Fibroblasts are primarily considered as cells that support organ structures and are currently
receiving attention for their roles in regulating immune responses in health and disease …

The long non-coding RNA HOTAIR contributes to joint-specific gene expression in rheumatoid arthritis

M Elhai, R Micheroli, M Houtman, M Mirrahimi… - Nature …, 2023 - nature.com
Although patients with rheumatoid arthritis (RA) typically exhibit symmetrical joint
involvement, some patients develop alternative disease patterns in response to treatment …

The chronological evolution of fluorescent GPCR probes for bioimaging

Y Wu, B Zhang, H Xu, M He, X Deng, L Zhang… - Coordination Chemistry …, 2023 - Elsevier
Abstract Scientists Robert J. Lefkowitz and Brian K. Kobilka won the Nobel Prize in 2012 for
reporting a groundbreaking discovery that revealed a crucial member of the receptor family …

Low dose methotrexate impaired T cell transmigration through down-regulating CXCR4 expression in rheumatoid arthritis

L Ding, D Park, B Gao, L Wu, M Li, H Abedelhakim… - 2023 - researchsquare.com
Background CXC chemokine CXCL12 is involved in the pathological development of
rheumatoid arthritis (RA) through abnormal migration of peripheral immune cells in the joint …

EPI-X4 als Peptid-Biomarker für die Diagnose und Prognose der akuten Graft-versus-Host-Disease

SS Sauer - 2023 - oparu.uni-ulm.de
Das Peptid EPI-X4 (Endogenous Peptide Inhibitor of CXCR4) wurde in der Literatur als Teil
eines Polypeptidmusters beschrieben, welches zur Diagnose einer akuten GvHD geeignet …

[PDF][PDF] The distinct and aggressive pathogenesis of arthritis in children with Down syndrome

SSY Foo - 2023 - tara.tcd.ie
In the healthy synovium, FLS are the main stromal cells and are involved in maintaining joint
homeostasis. They secrete ECM molecules into the SF which lubricate and protect the joint …

Sex-Based Disparities in Leukocyte Migration and Activation in Response to Inhalation Lung Injury: Role of SDF-1/CXCR4 Signaling

T Chatterjee, TL Lewis, I Arora, AE Gryshyna… - Cells, 2023 - mdpi.com
The aim of the study was to determine whether sex-related differences exist in immune
response to inhalation lung injury. C57BL/6 mice were exposed to Cl2 gas (500 ppm for 15 …

Compositions and methods for the treatment of toxic gas exposure

S Aggarwal - US Patent App. 17/969,836, 2023 - Google Patents
HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C [C@@
H](OCCO)[C@ H](OC) C [C@@ H] 1C [C@@ H](C)[C@ H] 1OC (= O)[C@@ H] 2CCCCN2C …