The mitochondrial protease Lonp1 is a multifunctional enzyme that regulates crucial
mitochondrial functions, including the degradation of oxidized proteins, folding of imported …

During hypoxia, FUNDC1 acts as a mitophagy receptor and accumulates at the ER
(endoplasmic reticulum)-mitochondria contact sites (EMC), also called mitochondria …

Significance: Cells depend on well-functioning mitochondria for essential processes such as
energy production, redox signaling, coordination of metabolic pathways, and cofactor …

The LONRF family of proteins consists of three isozymes, LONRF1–3, which harbors RING
(really interesting new gene) domain and Lon substrate binding domain. We have recently …

With the advancement in novel drug discovery, biologically active compounds are
considered pharmacological tools to understand complex biological mechanisms and the …

Background: CODAS syndrome (MIM 600373) is a multi-system developmental disorder
characterized by cerebral, ocular, dental, auricular, and skeletal anomalies. CODAS …

Lumbar spinal stenosis (LSS) is caused by the compression of the nerve root or cauda
equina nerve by stenosis of the lumbar spinal canal or intervertebral foramen, and is …

During hypoxia, FUNDC1 acts as a mitophagy receptor and accumulates at the ER
(endoplasmic reticulum)-mitochondria contact sites (EMC), also called mitochondria …

Autophagy, a critical degradation mechanism of various intracellular components through
the formation of double-bilayered membrane vesicles called autophagosomes and its fusion …

The hexameric Lon protein is an ATP-dependent protease residing in the mitochondrial
matrix. The Lon protein is the product of the nuclear LONP1 gene and plays a crucial role in …