Importance Approximately 20% to 30% of patients admitted to an intensive care unit have
sepsis. While fluid therapy typically begins in the emergency department, intravenous fluids …

Sepsis is a clinical syndrome encompassing physiologic and biological abnormalities
caused by a dysregulated host response to infection. Sepsis progression into septic shock is …

Importance Patients with septic shock undergo adrenergic stress, which affects cardiac,
immune, inflammatory, and metabolic pathways. β-Blockade may attenuate the adverse …

Background Intensivists target different blood pressure component values to manage
intensive care unit (ICU) patients with sepsis. We aimed to evaluate the relationship …

Septic shock is a common condition associated with hypotension and organ dysfunction. It is
associated with high mortality rates of up to 60% despite the best recommended …

Sepsis, defined as the life-threatening dysregulated host response to an infection leading to
organ dysfunction, is considered as one of the leading causes of mortality worldwide …

Sepsis causes significant morbidity and mortality worldwide. Resuscitation is a cornerstone
of management. This review covers five areas of evolving practice in the management of …

Background It is unclear how often survival benefits observed in single-center randomized
controlled trials (sRCTs) involving critically ill patients are confirmed by subsequent …

Purpose To evaluate the impact of active fluid de-resuscitation on mortality in critically ill
patients with septic shock. Methods A systematic search was performed on PubMed …

The importance of fluid resuscitation therapy during the early stages of sepsis management
is a well-established principle. Current Surviving Sepsis Campaign (SSC) guidelines …