A functional account of stimulation-based aerobic glycolysis and its role in interpreting BOLD signal intensity increases in neuroimaging experiments
In aerobic glycolysis, oxygen is abundant, and yet cells metabolize glucose without using it,
decreasing their ATP per glucose yield by 15-fold. During task-based stimulation, aerobic …
decreasing their ATP per glucose yield by 15-fold. During task-based stimulation, aerobic …
[HTML][HTML] Not all discounts are created equal: Regional activity and brain networks in temporal and effort discounting
Reward outcomes associated with costs like time delay and effort investment are generally
discounted in decision-making. Standard economic models predict rewards associated with …
discounted in decision-making. Standard economic models predict rewards associated with …
Pharmacological characterisation of the effort for reward task as a measure of motivation for reward in male mice
C Marangoni, M Tam, ESJ Robinson, MG Jackson - Psychopharmacology, 2023 - Springer
Rationale Motivational deficits are a common symptom shared across multiple psychiatric
and neurodegenerative disorders. Effort-based decision-making tasks are a translatable …
and neurodegenerative disorders. Effort-based decision-making tasks are a translatable …
Effort cost of harvest affects decisions and movement vigor of marmosets during foraging
P Hage, IK Jang, V Looi, MA Fakharian, SP Orozco… - Elife, 2023 - elifesciences.org
Our decisions are guided by how we perceive the value of an option, but this evaluation also
affects how we move to acquire that option. Why should economic variables such as reward …
affects how we move to acquire that option. Why should economic variables such as reward …
Effects of the atypical antipsychotic and D3/D2 dopamine partial agonist cariprazine on effort-based choice behavior: implications for modeling avolition
A Ecevitoglu, GA Edelstein, RE Presby, RA Rotolo… - …, 2023 - Springer
Rationale Cariprazine is an atypical antipsychotic that acts as a D3/D2 receptor partial
agonist. In addition to treating positive symptoms of schizophrenia, cariprazine may have …
agonist. In addition to treating positive symptoms of schizophrenia, cariprazine may have …
Accumbal adenosine A2A receptor inactivation biases for large and costly rewards in the effort-but not delay-based decision making
X Sun, M Liu, X Xu, C Shi, L Zhang, Z Yao, J Chen… - …, 2023 - Elsevier
The cost-benefit decision-making (CBDM) is critical to normal human activity and a
diminished willingness to expend effort to obtain rewards is a prevalent/noted characteristic …
diminished willingness to expend effort to obtain rewards is a prevalent/noted characteristic …
Effort-related effects of chronic administration of the DA D2 receptor antagonist haloperidol via subcutaneous programmable minipumps: Reversal by co …
RA Rotolo, A Ecevitoglu, RE Presby, H Lindgren… - …, 2023 - Springer
Rationale Long-acting antipsychotics such as haloperidol decanoate are becoming more
commonly used. Long-acting depot formulations have several advantages, but secondary …
commonly used. Long-acting depot formulations have several advantages, but secondary …
Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors
Dopamine release in striatal circuits, including the nucleus accumbens (NAc), tracks
separable features of reward such as motivation and reinforcement. However, the cellular …
separable features of reward such as motivation and reinforcement. However, the cellular …
The role of dorsomedial striatum adenosine 2A receptors in the loss of goal-directed behaviour
Abstract Rationale Adenosine A2A receptors (A2AR) in the dorsal striatum have been
implicated in goal-directed behaviour. While activation of these receptors with several …
implicated in goal-directed behaviour. While activation of these receptors with several …
Dopamine D1 receptor and effort-based decision making in rats: The moderating effect of sex
KM Witt, DN Harper, BA Ellenbroek - Progress in Neuro …, 2023 - Elsevier
Dopamine is a modulating factor in effort-based decision-making, and emerging evidence
from pharmacological research suggests that the dopamine D1 receptor is the primary …
from pharmacological research suggests that the dopamine D1 receptor is the primary …