In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a
promising immunotherapeutic approach to fight cancers. This approach consists of …

Classically, superoxide anion O2•− and reactive oxygen species ROS play a dual role. At
the physiological balance level, they are a by-product of O2 reduction, necessary for cell …

When the production of reactive oxygen species (ROS) is overloaded surpassing the
capacity of the reductive rheostat, mammalian cells undergo a series of oxidative damage …

Several mechanisms and cell types are involved in the regulation of the immune response.
These include mostly regulatory T cells (Tregs), regulatory macrophages (Mregs), myeloid …

Tumour-associated macrophages (TAMs) are crucial components of the tumour
microenvironment and play a significant role in tumour development and drug resistance by …

Nuclear factor κB (NF-κB) is a dimeric transcription factor constituted by two of five protein
family members. It plays an essential role in inflammation and immunity by regulating the …

Diabetes mellitus is a chronically inflamed disease that predisposes to delayed fracture
healing. Macrophages play a key role in the process of fracture healing by undergoing …

Gelatin methacryloyl (GelMA), a photocurable hydrogel, is widely used in 3D culture,
particularly in 3D bioprinting, due to its high biocompatibility, tunable physicochemical …

Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

Macrophages represent heterogeneous cell population with important roles in defence
mechanisms and in homoeostasis. Tissue macrophages from diverse anatomical locations …