Osteoporosis (OP) is a systemic disease characterized by decreased bone mass and
degeneration of bone microstructure. In recent years, more and more researches have …

At the turn of the century, researchers discovered a unique subtype of T helper cells that
secretes IL-17 and defined it as Th17. The latest study found that Th17 cells play both …

Epidemiological studies have indicated an association between statin use and reduced
incidence of colorectal cancer (CRC), and work in preclinical models has demonstrated a …

Tumor‑associated macrophages (TAMs) are crucial cells of the tumor microenvironment
(TME), which belong to the innate immune system and regulate primary tumor growth …

Intestinal epithelial cells (IECs) at the internal/external interface orchestrate the mucosal
immune response, and IEC dysfunction has been linked to multiple inflammatory diseases …

The differentiation of CD4+ T cells is a crucial component of the immune response. The
spleen and thymus, as immune organs, are closely associated with the differentiation and …

Psoriasis and inflammatory bowel disease (IBD) have a similar etiology, including abnormal
activation of T cells. Differentially expressed genes (DEGs) analysis was used to search for …

Epigenetic reprogramming is a promising therapeutic strategy for aggressive cancers, but its
limitations in vivo remain unclear. Here, we showed, in detailed studies of data regarding …

The TANK-binding kinase 1 (TBK1) is a cytoplasmic, serine/threonine kinase and a critical
activator of the innate immune system. Reports have implicated TBK1 as a promoter of …

Alteration of the gut microbiota has been linked to non-infectious diseases such as obesity
and allergy. However, mechanisms linking dysbiosis with non-infectious diseases or …