Mitochondria: how eminent in ageing and neurodegenerative disorders?

C Bamshad, N Najafi-Ghalehlou… - Human Cell, 2023 - Springer
Numerous factors are implicated in the onset and progression of ageing and
neurodegenerative disorders, with defects in cell energy supply and free radicals regulation …

[HTML][HTML] Coaggregation of polyglutamine (polyQ) proteins is mediated by polyQ-tract interactions and impairs cellular proteostasis: Coaggregation of polyQ proteins

JY Hong, JY Wang, HW Yue, XL Zhang… - Acta Biochimica et …, 2023 - ncbi.nlm.nih.gov
Nine polyglutamine (polyQ) proteins have already been identified that are considered to be
associated with the pathologies of neurodegenerative disorders called polyQ diseases, but …

The role of calpains in the molecular pathogenesis of spinocerebellar ataxia type 17

SC Anger - 2023 - tobias-lib.ub.uni-tuebingen.de
Spinocerebellar ataxia type 17 (SCA17) is an autosomal-dominantly inherited
neurodegenerative disease predominantly characterized with ataxia, dysarthria, chorea …

Detection and characterization of Huntingtin-protein interactions using resonance energy transfer methodologies

M Dominguez Martinez - 2023 - edoc.hu-berlin.de
HTT is a protein involved in a plethora of cellular processes through its association with
several interaction partners. Furthermore, a mutation in the HTT gene, causes a disease …