Mutation effects on structure and dynamics: adaptive evolution of the SARS-CoV-2 main protease
The main protease of SARS-CoV-2 (Mpro) plays a critical role in viral replication; although it
is relatively conserved, Mpro has nevertheless evolved over the course of the COVID-19 …
is relatively conserved, Mpro has nevertheless evolved over the course of the COVID-19 …
A cold‐active esterase enhances mesophilic properties through Mn2+ binding
A key aspect of adaptation to cold environments is the production of cold‐active enzymes by
psychrophilic organisms. These enzymes not only have high activity at low temperatures, but …
psychrophilic organisms. These enzymes not only have high activity at low temperatures, but …
Exploitation of active site flexibility-low temperature activity relation for engineering broad range temperature active enzymes
S Dasetty, JWP Zajac, S Sarupria - Molecular Systems Design & …, 2023 - pubs.rsc.org
Differences in the structural and thermodynamic properties of enzymes adapted to different
temperatures indicate that broad range temperature active enzymes can be designed by …
temperatures indicate that broad range temperature active enzymes can be designed by …