The mechanism and therapy of aortic aneurysms

J Gao, H Cao, G Hu, Y Wu, Y Xu, H Cui, HS Lu… - Signal transduction and …, 2023 - nature.com
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

Diagnostic biomarkers and aortic dissection: a systematic review and meta-analysis

H Chen, Y Li, Z Li, Y Shi, H Zhu - BMC Cardiovascular Disorders, 2023 - Springer
Background Aortic dissection (AD) is a serious and fatal vascular disease. The earlier the
condition of AD patients can be assessed precisely, the more scientifically controlled the …

Targeting endothelial tight junctions to predict and protect thoracic aortic aneurysm and dissection

X Yang, C Xu, F Yao, Q Ding, H Liu, C Luo… - European Heart …, 2023 - academic.oup.com
Aims Whether changes in endothelial tight junctions (TJs) lead to the formation of thoracic
aortic aneurysm and dissection (TAAD) and serve as an early indicator and therapeutic …

Hybrid discrete-continuum multiscale model of tissue growth and remodeling

E Gacek, RR Mahutga, VH Barocas - Acta Biomaterialia, 2023 - Elsevier
Tissue growth and remodeling (G&R) is often central to disease etiology and progression, so
understanding G&R is essential for understanding disease and developing effective …

Causal role for neutrophil elastase in thoracic aortic dissection in mice

M Yang, X Zhou, SWA Pearce, Z Yang… - … and Vascular Biology, 2023 - Am Heart Assoc
BACKGROUND: Thoracic aortic dissection (TAD) is a life-threatening aortic disease without
effective medical treatment. Increasing evidence has suggested a role for NE (neutrophil …

Genetic insights on the relation of vascular risk factors and cervical artery dissection

Q Le Grand, L Ecker Ferreira, TM Metso… - Journal of the American …, 2023 - jacc.org
Background The association between vascular risk factors and cervical artery dissections
(CeADs), a leading cause of ischemic stroke (IS) in the young, remains controversial …

Molecular and cellular mechanisms involved in aortic wall aneurysm development

I Bararu Bojan, CE Pleșoianu, OV Badulescu… - Diagnostics, 2023 - mdpi.com
Aortic aneurysms represent a very common pathology that can affect any segment of the
aorta. These types of aneurysms can be localized on the thoracic segment or on the …

[HTML][HTML] Integrated bulk and scRNA sequence identified anoikis-related diagnostic biomarkers and potential association with immune infiltration in type A aortic …

K Feng, Z Zhang, J Luo, W Wang, T Li, J Luo… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Type-A aortic dissection (TAAD) is common life-threatening cardiovascular diseases with
high-morbidity and mortality but the concrete etiology of disease remains unclear, which …

Comparative analysis of patient-specific aortic dissections through computational fluid dynamics suggests increased likelihood of degeneration in partially thrombosed …

S Moretti, F Tauro, M Orrico, N Mangialardi, AL Facci - Bioengineering, 2023 - mdpi.com
Aortic dissection is a life-threatening vascular disease associated with high rates of
morbidity and mortality, especially in medically underserved communities. Understanding …

[HTML][HTML] Impact of retraining a deep learning algorithm for improving guideline-compliant aortic diameter measurements on non-gated chest CT

FL Piccolo, D Hinck, M Segeroth, J Sperl… - European Journal of …, 2023 - Elsevier
Purpose/objective Reliable detection of thoracic aortic dilatation (TAD) is mandatory in
clinical routine. For ECG-gated CT angiography, automated deep learning (DL) algorithms …