Trisomy 21, the genetic cause of Down syndrome (DS), is the most common congenital
chromosomal anomaly. It is associated with a 20-fold increased risk of acute lymphoblastic …

Introduction The suitability of whole-genome sequencing (WGS) as the sole method to
detect clinically relevant genomic aberrations in B-cell acute lymphoblastic leukemia (ALL) …

Philadelphia chromosome-like (Ph-like) ALL is a recent subtype of acute lymphoblastic
leukemia. Although it does not express the BCR-ABL fusion gene, it has a behavior like true …

Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk subgroup of B cell
ALL with distinct genotypes, unified by gene expression profile similar to Ph-positive ALL …

Advancing cure rates for high-risk acute lymphoblastic leukemia (ALL) has been limited by
the lack of agents that effectively kill leukemic cells, sparing normal hematopoietic tissue …

Acute lymphoblastic leukemia (ALL) can be classified into different subgroups based on
recurrent genetic alterations. Here, targeted RNA sequencing was used to identify the novel …

Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is an intractable
disease and most cases harbor genetic alterations that activate JAK or ABL signaling. The …

Overexpression of cytokine receptor-like factor 2 (CRLF2) resulting from its genomic
rearrangement is the most frequent genetic alteration found in Philadelphia chromosome …

The objective of this study is to explore the clinical features and outcomes of pediatric
patients with acute lymphoblastic leukemia (ALL) harboring JAK-STAT signaling pathway …

Children with Down syndrome (DS) have a 10-to 20-fold greater predisposition to develop
acute leukemia compared to the general population, with a skew towards myeloid leukemia …