Neonatal Infections are among the most common reasons for admission to the intensive
care unit. Neonatal sepsis (NS) significantly contributes to mortality rates. Empiric antibiotic …

Significant interindividual and intraindividual variations on cytochrome P450 (CYP)-
mediated drug metabolism exist in the general population globally. Genetic polymorphisms …

Physiologically based pharmacokinetic (PBPK) modeling is an approach to predicting drug
pharmacokinetics, using knowledge of the human physiology involved and drug …

Purpose There is marked heterogeneity in treatment response of atomoxetine in patients
with attention deficit/hyperactivity disorder (ADHD), especially for the pediatric population …

Pharmacokinetics varies widely between children. Many factors play an important role in this
variability, such as ontogeny, pharmacogenetics, gender, comorbidities, and drug-drug …

A 32-week fetus with tachycardia and bradycardia, diagnosed with torsades de pointes,
atrioventricular block, and sinus bradycardia due to a de novo KCNH2 mutation was …

Flecainide is a class IC antiarrhythmic utilized in prophylaxis of refractory paroxysmal
supraventricular tachycardias in pediatric populations. Despite being a highly effective …

Pharmacogenetics focuses on heritable factors that influence drug responses. For a given
drug and patient, pharmacogenetics aims to optimise the intended therapeutic benefits …