Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital
participant in primary cellular functions, such as proliferation, survival, migration, and …

Tumor development relies on a complex and aberrant tissue environment in which cancer
cells receive the necessary nutrients for growth, survive through immune escape, and …

A challenge in developing proteolysis targeting chimeras (PROTACs) is the establishment of
a universal platform applicable in multiple scenarios for precise degradation of proteins of …

Targeted protein degradation (TPD) has emerged as a promising approach for drug
development, particularly for undruggable targets. TPD technology has also been …

Epidermal growth factor receptor (EGFR) is an oncogenic drug target and plays a critical role
in several cellular functions including cancer cell growth, survival, proliferation …

The gaining importance of Targeted Protein Degradation (TPD) and PROTACs (PROteolysis-
TArgeting Chimeras) have drawn the scientific community's attention. PROTACs are …

Targeted protein degradation (TPD) aids in developing novel bifunctional small-molecule
degraders and eliminates proteins of interest. The TPD approach shows promising results in …

Abstract Targeted Protein Modification (TPM) is an umbrella term encompassing numerous
tools and approaches that use bifunctional agents to induce a desired modification over the …

BET proteins, which influence gene expression and contribute to the development of cancer,
are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic …

Ferroptosis is a new type of regulated, non-apoptotic cell death driven by iron-dependent
phospholipid peroxidation. Inducing cell ferroptosis by inactivating glutathione peroxidase 4 …