The human body is inhabited by numerous bacteria, fungi, and viruses, and each part has a
unique microbial community structure. The gastrointestinal tract harbors approximately 100 …

Excessive fat accumulation in the liver has become a major health threat worldwide.
Unresolved fat deposition in the liver can go undetected until it develops into fatty liver …

The gut microbiota interacts with intestinal epithelial cells through microbial metabolites to
regulate the release of gut hormones. We investigated whether the gut microbiota affects the …

With the increasing prevalence of energy metabolism disorders such as diabetes,
cardiovascular disease, obesity, and anorexia, the regulation of feeding has become the …

Abstract Context Bile acids (BAs) are pivotal signaling molecules that regulate energy
metabolism and inflammation. Recent epidemiological studies have reported specific …

Primary and secondary bile acids (BAs) influence metabolism and inflammation, and the gut
microbiome modulates levels of BAs. We systematically explore the host genetic, gut …

Bile acids are acknowledged as signaling molecules involved in metabolic syndrome. The
Takeda G protein-coupled receptor 5 (TGR5) functions as a significant bile acid receptor …

This review article explores the potential of metformin, a medication commonly used for type
2 diabetes, as an antiviral and anti-inflammatory agent in the context of coronavirus disease …

Anxiety disorder is a prevalent neuropsychiatric disorder that afflicts 7.3%~ 28.0% of the
world's population. Bile acids are synthesized by hepatocytes and modulate metabolism via …

G protein-coupled receptors (GPCRs) are a large family of membrane protein receptors, and
Takeda G protein-coupled receptor 5 (TGR5) is a member of this family. As a membrane …