Cancer epigenetics in clinical practice

V Davalos, M Esteller - CA: a cancer journal for clinicians, 2023 - Wiley Online Library
Cancer development is driven by the accumulation of alterations affecting the structure and
function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic …

Electrochemical biosensors for whole blood analysis: recent progress, challenges, and future perspectives

S Li, H Zhang, M Zhu, Z Kuang, X Li, F Xu… - Chemical …, 2023 - ACS Publications
Whole blood, as one of the most significant biological fluids, provides critical information for
health management and disease monitoring. Over the past 10 years, advances in …

DNA damage, demethylation and anticancer activity of DNA methyltransferase (DNMT) inhibitors

ABA Laranjeira, MG Hollingshead, D Nguyen… - Scientific Reports, 2023 - nature.com
Role of DNA damage and demethylation on anticancer activity of DNA methyltransferase
inhibitors (DNMTi) remains undefined. We report the effects of DNMT1 gene …

[HTML][HTML] Vision transformer-based weakly supervised histopathological image analysis of primary brain tumors

Z Li, Y Cong, X Chen, J Qi, J Sun, T Yan, H Yang, J Liu… - IScience, 2023 - cell.com
Diagnosis of primary brain tumors relies heavily on histopathology. Although various
computational pathology methods have been developed for automated diagnosis of primary …

A qPCR technology for direct quantification of methylation in untreated DNA

KK Bendixen, M Mindegaard, S Epistolio… - Nature …, 2023 - nature.com
DNA methylation is important for gene expression and alterations in DNA methylation are
involved in the development and progression of cancer and other major diseases. Analysis …

Multiplex Digital Methylation‐Specific PCR for Noninvasive Screening of Lung Cancer

Y Zhao, CM O'Keefe, K Hsieh, L Cope… - Advanced …, 2023 - Wiley Online Library
There remains tremendous interest in developing liquid biopsy assays for detection of
cancer‐specific alterations, such as mutations and DNA methylation, in cell‐free DNA …

Methylation-sensitive transcription-enhanced single-molecule biosensing of DNA methylation in cancer cells and tissues

Z Han, F Ma, C Zhang - Analytica Chimica Acta, 2023 - Elsevier
As a major epigenetic modification, DNA methylation participates in diverse cellular
functions and emerges as a promising biomarker for disease diagnosis and monitoring …

Genome-wide characterization and expression analysis of MYB transcription factors in Chrysanthemum nankingense

P Ai, J Xue, Z Shi, Y Liu, Z Li, T Li, W Zhao, MA Khan… - BMC Plant …, 2023 - Springer
Background Chrysanthemum is a popular ornamental plant worldwide. MYB (v-myb avian
myeloblastosis viral oncogene homolog) transcription factors play an important role in …

Korean red ginseng attenuates particulate matter-induced senescence of skin keratinocytes

KA Kang, MJ Piao, PDSM Fernando, HMUL Herath… - Antioxidants, 2023 - mdpi.com
Skin is a direct target of fine particulate matter (PM2. 5), as it is constantly exposed. Herein,
we investigate whether Korean red ginseng (KRG) can inhibit PM2. 5-induced senescence …

The effect of nanomaterials on DNA methylation: A review

A Valente, L Vieira, MJ Silva, C Ventura - Nanomaterials, 2023 - mdpi.com
DNA methylation is an epigenetic mechanism that involves the addition of a methyl group to
a cytosine residue in CpG dinucleotides, which are particularly abundant in gene promoter …