Defining urinary tract infection (UTI) is complex, as numerous clinical and diagnostic
parameters are involved. In this systematic review, we aimed to gain insight into how UTI is …

Emerging resistance to all available antibiotics highlights the need to develop new
antibiotics with novel mechanisms of action. Most of the currently used antibiotics target …

Background Traditional end points used in registrational randomized, controlled trials
(RCTs) often do not allow for complete interpretation of the full range of potential clinical …

While urinary tract infections (UTIs) are one of the most common types of infections globally,
the wide variety of presentations and of severity of disease can make it difficult to manage …

Multidrug resistance (MDR) pathogens are usually associated with higher morbidity and
mortality rates. Flavonoids are good candidates for the development of new potential …

Multidrug-resistant (MDR)/extensively drug-resistant (XDR) Pseudomonas aeruginosa is
emerging as a major threat related to adverse patient outcomes. The goal of this review is to …

The clinical relevance of bacteriuria following antibiotic treatment of complicated urinary tract
infections in clinical trials remains controversial. We evaluated the impact of urine …

Bacteremia and endocarditis are two clinical syndromes that, for decades, were managed
exclusively with parenteral antimicrobials, irrespective of a given patient's clinical condition …

Human Pseudomonas infections have high morbidity and mortality rates. Pseudomonas
bacteria can cause sepsis or septic shock; they produce biofilm and commonly exhibit a …

NDM-expressing Escherichia coli infections are challenging to treat, due to limited treatment
options. E. coli with four-amino acid inserts (YRIN/YRIK) are also common in India and it has …