Emerging evidence indicates that DNA methylation plays an important role in the initiation
and progression of nasopharyngeal carcinoma (NPC). DNAJA4 is hypermethylated in NPC …

Protein homeostasis is the basis of normal life activities, and the proteasome family plays an
extremely important function in this process. The proteasome 20S is a concentric circle …

The receptor for activated C kinase 1 (RACK1) is a key scaffolding protein with
multifunctional and multifaceted properties. By mediating protein-protein interactions …

Breast cancer metastasis is the primary cause of mortality of patients with breast cancer. The
present study aimed to explore the role and underlying mechanisms of IGJ in the invasion …

Background The ubiquitin–proteasome and autophagy-lysosomal systems collaborate in
regulating the levels of intracellular proteins. Dysregulation of protein homeostasis is a …

Background Pancreatic ductal adenocarcinoma (PDAC) has been widely studied at
multiomics level. However, little is known about its specific ubiquitination, a major post …

The drug therapy for non-small cell lung cancer (NSCLC) have always been issues of
poisonous side effect, acquired drug resistance and narrow applicable population. In this …

Simple Summary Certain life stages, known as critical periods, during growth and
development are thought to be important for later-life breast cancer initiation and …

At present, chemotherapy is the most effective strategy for treating triple-negative breast
cancer (TNBC), but its efficacy was limited by the development of chemo-resistance. The …

Pulmonary hypertension (PH) is a cardiopulmonary vascular disease that acutely endangers
human health and can be fatal. It progresses rapidly and has a high mortality rate. Its …