[HTML][HTML] Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies

ME Bahar, HJ Kim, DR Kim - Signal transduction and targeted therapy, 2023 - nature.com
Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality,
underscores the urgent need for enhanced insights into the molecular and cellular …

Recent developments and challenges in molecular-targeted therapy of non-small-cell lung cancer

S Rohilla, M Singh, SI Alzarea… - Journal of …, 2023 - dl.begellhouse.com
Treatment of lung cancer with conventional therapies, which include radiation, surgery, and
chemotherapy results in multiple undesirable adverse or side effects. The major clinical …

[HTML][HTML] The role of miR-128 in cancer development, prevention, drug resistance, and immunotherapy

HS Budi, LA Younus, MH Lafta, S Parveen… - Frontiers in …, 2023 - frontiersin.org
A growing body of evidence has revealed that microRNA (miRNA) expression is
dysregulated in cancer, and they can act as either oncogenes or suppressors under certain …

[HTML][HTML] CC-115 mediates GSDME-dependent pyroptosis in lung adenocarcinoma through the akt/bax pathway

T Zhang, MQ Liu, GS Xie, DM Wu, PW Luo, T Liu… - Journal of …, 2023 - ncbi.nlm.nih.gov
Chemotherapeutic agents remain the first-line treatment for solid tumors, including lung
cancer, but chemotherapy resistance is hampering global efforts to treat this disease. CC …

Role of exosomal miRNA in chemotherapy resistance of Colorectal cancer: A systematic review

M Maleki, A Golchin, S Javadi… - Chemical Biology & …, 2023 - Wiley Online Library
The third most common malignancy has been identified as Colorectal cancer (CRC) that
conducive to death in most cases. Chemoresistance is a common obstacle to CRC …

[HTML][HTML] circ_0000376 knockdown suppresses non-small cell lung cancer cell tumor properties by the miR-545-3p/PDPK1 pathway

C Sun, H Guan, J Li, Y Gu - Open Medicine, 2023 - degruyter.com
Non-small cell lung cancer (NSCLC) accounts for 80% of total lung cancers, which are the
main killer of cancer-related death worldwide. Circular RNA (circRNA) has been found to …

Exploring the impact of miR-128 in inflammatory diseases: A comprehensive study on autoimmune diseases

R Margiana, HH Kzar, F Hussam, NM Hameed… - … -Research and Practice, 2023 - Elsevier
Abstract microRNAs (miRNAs) play a crucial role in various biological processes, including
immune system regulation, such as cell proliferation, tolerance (central and peripheral), and …

[HTML][HTML] Current landscape of miRNAs and TGF‐β signaling in lung cancer progression and therapeutic targets

BM Hussen, SJ Saleem, SR Abdullah… - Molecular and Cellular …, 2023 - Elsevier
Lung cancer (LC) is the primary reason for cancer-associated fatalities globally. Due to both
tumor-suppressing and tumor-promoting activities, the TGF-β family of growth factors is …

Slit2/Robo1 signaling inhibits small‐cell lung cancer by targeting β‐catenin signaling in tumor cells and macrophages

DK Ahirwar, B Peng, M Charan, S Misri… - Molecular …, 2023 - Wiley Online Library
Small‐cell lung cancer (SCLC) is an aggressive neuroendocrine subtype of lung cancer with
poor patient prognosis. However, the mechanisms that regulate SCLC progression and …

Chemoresistance Mechanisms in Non-Small Cell Lung Cancer—Opportunities for Drug Repurposing

R Kaur, PK Suresh - Applied Biochemistry and Biotechnology, 2023 - Springer
Globally, lung cancer contributes significantly to the public health burden–associated
mortality. As this form of cancer is insidious in nature, there is an inevitable diagnostic delay …