[HTML][HTML] Roles of host proteases in the entry of SARS-CoV-2

A Zabiegala, Y Kim, KO Chang - Animal Diseases, 2023 - Springer
The spike protein (S) of SARS-CoV-2 is responsible for viral attachment and entry, thus a
major factor for host susceptibility, tissue tropism, virulence and pathogenicity. The S is …

[HTML][HTML] SARS-coV-2 spike-mediated entry and its regulation by host innate immunity

S Yu, H Hu, Q Ai, R Bai, K Ma, M Zhou, S Wang - Viruses, 2023 - mdpi.com
The constantly evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants of concern (VOC) fuel the worldwide coronavirus disease (COVID-19) pandemic …

Potential targets of severe acute respiratory syndrome coronavirus 2 of clinical drug fluvoxamine: docking and molecular dynamics studies to elucidate viral action

SK Panda, PSS Gupta, MK Rana - Cell Biochemistry and …, 2023 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has continued evolving for
survival and adaptation by mutating itself into different variants of concern, including …

[HTML][HTML] Decoding the bidirectional relationship between gut microbiota and COVID-19

T Ralli, Z Saifi, A Rathee, V Aeri, K Kohli - Heliyon, 2023 - cell.com
From late 2019, whole world has been facing COVID-19 pandemic which is caused by
SARS-CoV-2 virus. This virus primarily attacks the respiratory tract and enter host cell by …

[HTML][HTML] Antibody-mediated spike activation promotes cell-cell transmission of SARS-CoV-2

S Yu, X Zheng, Y Zhou, Y Gao, B Zhou, Y Zhao… - PLoS …, 2023 - journals.plos.org
The COVID pandemic fueled by emerging SARS-CoV-2 new variants of concern remains a
major global health concern, and the constantly emerging mutations present challenges to …

[HTML][HTML] Airway proteolytic control of pneumococcal competence

H Echlin, A Iverson, U Sardo, JW Rosch - PLoS Pathogens, 2023 - journals.plos.org
Streptococcus pneumoniae is an opportunistic pathogen that colonizes the upper respiratory
tract asymptomatically and, upon invasion, can lead to severe diseases including otitis …

[HTML][HTML] Molecular mechanisms of human coronavirus NL63 infection and replication

G Castillo, JC Mora-Díaz, M Breuer, P Singh, RK Nelli… - Virus Research, 2023 - Elsevier
Abstract Human coronavirus NL63 (HCoV-NL63) is spread globally, causing upper and
lower respiratory tract infections mainly in young children. HCoV-NL63 shares a host …

[HTML][HTML] Ocular symptoms associated with COVID-19 are correlated with the expression profile of mouse SARS-CoV-2 binding sites

J Brechbühl, F Ferreira, AC Lopes, E Corset, N Gilliand… - Viruses, 2023 - mdpi.com
The COVID-19 pandemic has engendered significant scientific efforts in the understanding
of its infectious agent SARS-CoV-2 and of its associated symptoms. A peculiar characteristic …

[HTML][HTML] Bacterial Proteases as Potentially Exploitable Modulators of SARS-CoV-2 Infection: Logic from the Literature, Informatics, and Inspiration from the Dog

GH Lushington, A Linde, T Melgarejo - BioTech, 2023 - mdpi.com
(1) Background: The COVID-19 pandemic left many intriguing mysteries. Retrospective
vulnerability trends tie as strongly to odd demographics as to exposure profiles, genetics …

Sequential Glycosylations at the Multibasic Cleavage Site of SARS-CoV-2 Spike Protein Regulate Viral Activation, Assembly, and Infection

S Wang, W Ran, L Sun, Q Fan, Y Zhao, B Wang… - 2023 - researchsquare.com
The multibasic furin cleavage site at the S1/S2 boundary of the spike protein (S protein) is a
hallmark of SARS-CoV-2 and is essential for its increased infectivity. O-glycosylation near …