Recent advances in neoantigen research have accelerated the development of tumor
immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody …

The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling
pathway is a key pathway through which the host regulates immune responses by …

Despite the success of PD-1 blockade in melanoma and other cancers, effective treatment
strategies to overcome resistance to cancer immunotherapy are lacking,. Here we identify …

Lung cancer is the leading cause of cancer-related death worldwide. Although natural killer
(NK) cells are garnering interest as a potential anticancer therapy because they selectively …

Natural killer (NK) cells integrate heterogeneous signals for activation and inhibition using
germline-encoded receptors. These receptors are stochastically co-expressed, and their …

Chimeric antigen receptor (CAR) T cell therapy has been a great success in CD19+
hematological diseases. Natural killer (NK) CAR cells offer an alternative to CAR T cells with …

cGAS-STING signaling is a central component in the therapeutic action of most existing
cancer therapies. The accumulated knowledge of tumor immunoregulatory network in recent …

The ability to expand and activate natural Killer (NK) cells ex vivo has dramatically changed
the landscape in the development of novel adoptive cell therapies for treating cancer over …

Cancer is the second most common cause of death worldwide and remains one of the
critical public health problems of our time 1. Recently, immunotherapy has considerably …

In this review, we will provide a general understanding of NK cell biology, CAR-NK cell
advantages over CAR-T cell therapy, barriers to making NK cell immunotherapy viable, and …