Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …

Epilepsy is one of the most common neurological disorders. Although many factors
contribute to epileptogenesis, seizure generation is mostly linked to hyperexcitability due to …

Neonatal hypoxia causes cytotoxic neuronal swelling by the entry of ions and water. Multiple
water pathways have been implicated in neurons because these cells lack water channels …

Despite the fact that there are several drugs available for the treatment of epilepsy,
pharmacoresistance remains a major challenge in seizure control. Therefore, a significant …

Background Bumetanide, an inhibitor of the sodium-potassium-chloride cotransporter-1, has
been suggested as an adjunct to phenobarbital for treating neonatal seizures. Methods A …

During the critical period of postnatal development, brain maturation is extremely sensitive to
external stimuli. Newborn rodents already have functional somatosensory pathways and the …

Neuronal edema after excitotoxic brain insults results in neuronal injury and death. Osmotic
and surgical interventions designed to mitigate edema yield poor clinical outcomes …

Optogenetics has revolutionized neurobiological research by providing tools for modulating
neuronal activity. As these tools utilise light-activated ion fluxes, they afford new …

Febrile seizures are among the most common types of convulsions in children. Why young
children are susceptible to these events is rooted in fundamental steps of brain …

Despite the fact that there are several drugs available for the treatment of epilepsy,
pharmacoresistance remains a major challenge in seizure control. Therefore, a significant …